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Mouse Monoclonal GTBP antibody [3A10H7] (STJ98123)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MSH6 antibody, GTBP antibody,|DNA mismatch repair protein Msh6 antibody|G/T mismatch binding protein antibody|G/T mismatch-binding protein antibody|GTBP antibody|GTMBP antibody|hMSH6 antibody|HNPCC 5 antibody|HNPCC5 antibody|HSAP antibody|MSH 6 antibody|MSH6 antibody|MSH6_HUMAN antibody|mutS (E. coli) homolog 6 antibody|MutS alpha 160 kDa subunit antibody|MutS homolog 6 (E. coli) antibody|mutS homolog 6 antibody|MutS-alpha 160 kDa subunit antibody|p160 antibody|Sperm associated protein antibody|Anti-MSH6 antibody [EPR3945] (ab92471)
SCBT cat No: sc-137015|sc-271979|sc-10798|sc-1243|sc-1242|
GTBP Monoclonal Antibody
|Catalogue No.|| |
GTBP Monoclonal Antibody detects endogenous levels of GTBP protein.
Purified recombinant fragment of GTBP expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
GTBP Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GTBP Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
DNA mismatch repair protein Msh6 antibody, hMSH6 antibody, G/T mismatch-binding protein antibody, GTBP antibody, GTMBP antibody, MutS protein homolog 6 antibody, MutS-alpha 160 kDa subunit antibody, p160 antibody
|Protein names|| |
DNA mismatch repair protein Msh6 , hMSH6 , G/T mismatch-binding protein , GTBP , GTMBP , MutS protein homolog 6 , MutS-alpha 160 kDa subunit , p160
|Protein function|| |
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP–>ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated ‘Lys-36’ of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
|Involvement in disease|| |
Hereditary non-polyposis colorectal cancer 5 (HNPCC5) [MIM:614350]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term ‘suspected HNPCC’ or ‘incomplete HNPCC’ can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Mismatch repair cancer syndrome (MMRCS) [MIM:276300]: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The PWWP domain specifically recognizes and binds trimethylated ‘Lys-36’ of histone H3 (H3K36me3). / Belongs to the DNA mismatch repair MutS family. / Contains 1 PWWP domain.
|Protein post-translational modifications|| |
The N-terminus is blocked. / Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
|Protein cellular localization|| |
Nucleus / Chromosome
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St John’s Laboratory Ltd.
|Product type|| |
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