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Mouse Monoclonal HDAC3 antibody [7G6C5] (STJ98129)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
HDAC3 antibody,|HD3 antibody|HDAC 3 antibody|HDAC3 antibody|HDAC3_HUMAN antibody|Histone deacetylase 3 antibody|RPD3 2 antibody|RPD3 antibody|RPD3-2 antibody|SMAP45 antibody|Anti-HDAC3 antibody [Y415] (ab32369)
SCBT cat No: sc-130319|sc-81600|sc-136290|sc-376957|sc-17795|sc-11417|sc-8138|
HDAC3 Monoclonal Antibody
|Catalogue No.|| |
HDAC3 Monoclonal Antibody detects endogenous levels of HDAC3 protein.
Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
HDAC3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
HDAC3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone deacetylase 3 antibody, HD3 antibody, RPD3-2 antibody, SMAP45 antibody
|Protein names|| |
Histone deacetylase 3 , HD3 , RPD3-2 , SMAP45
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 ‘Lys-27’ (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress . / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 1 subfamily.
|Protein post-translational modifications|| |
Sumoylated in vitro.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Cytoplasm > cytosol
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St John’s Laboratory Ltd.
|Product type|| |
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