Mouse Monoclonal HDAC3 antibody [7G6C5] (STJ98129)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal HDAC3 antibody [7G6C5] (STJ98129)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HDAC3 antibody,|HD3 antibody|HDAC 3 antibody|HDAC3 antibody|HDAC3_HUMAN antibody|Histone deacetylase 3 antibody|RPD3 2 antibody|RPD3 antibody|RPD3-2 antibody|SMAP45 antibody|Anti-HDAC3 antibody [Y415] (ab32369)
SCBT cat No: sc-130319|sc-81600|sc-136290|sc-376957|sc-17795|sc-11417|sc-8138|

 

Name

HDAC3 Monoclonal Antibody

Catalogue No.

STJ98129

Reactivity

Human

Specificity

HDAC3 Monoclonal Antibody detects endogenous levels of HDAC3 protein.

Immunogen

Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

HDAC3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

HDAC3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone deacetylase 3 antibody, HD3 antibody, RPD3-2 antibody, SMAP45 antibody

Database links

Human UniProt/Swiss-Prot:O15379;Rat UniProt/Swiss-Port: Q6P6W3;Human Entrez Gene: 8841;Mouse Entrez Gene: 15183;Rat Entrez Gene: Rn.17284

Protein names

Histone deacetylase 3 , HD3 , RPD3-2 , SMAP45

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 ‘Lys-27’ (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress . / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

Belongs to the histone deacetylase family. HD type 1 subfamily.

Protein post-translational modifications

Sumoylated in vitro.

Protein cellular localization

Nucleus / Cytoplasm / Cytoplasm > cytosol

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HDAC3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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