Mouse Monoclonal HDAC4 antibody [7B2] (STJ98131)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal HDAC4 antibody [7B2] (STJ98131)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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HDAC4 antibody, KIAA0288 antibody,|AHO3 antibody|MEF2-interacting transcription repressor MITR antibody|MITR antibody|NY-CO-9 antibody|Anti-HDAC4 antibody (ab12172)
SCBT cat No: sc-46672|sc-365093|sc-48390|sc-365367|sc-11418|sc-56686|sc-5246|sc-5245|sc-11421|

 

Name

HDAC4 Monoclonal Antibody

Catalogue No.

STJ98131

Reactivity

Human

Specificity

HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.

Immunogen

Purified recombinant fragment of human HDAC4 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

HDAC4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

HDAC4 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone deacetylase 4 antibody, HD4 antibody,

Database links

Human UniProt/Swiss-Prot:P56524;Mouse UniPort/Swiss-Prot: Q6NZM9;Rat UniProt/Swiss-Port: Q99P99;Human Entrez Gene: 9759;Mouse Entrez Gene: 208727;Rat Entrez Gene: Rn.23483

Protein names

Histone deacetylase 4 , HD4 ,

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Protein tissue specificity

Ubiquitous.

Involvement in disease

Brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. . Note: The gene represented in this entry is involved in disease pathogenesis. HDAC4 point mutations and chromosomal microdeletions encompassing this gene have been found in BDMR patients (PubMed:20691407, PubMed:24715439, PubMed:23188045). However, HDAC4 haploinsufficiency is not fully penetrant and multiple genes may contribute to manifestation of the full phenotypic spectrum (PubMed:24715439, PubMed:23188045). .

Protein sequence and domain

The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. / Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein post-translational modifications

Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3. / Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HDAC4 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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