Mouse Monoclonal HFE antibody [3F1] (STJ98132)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal HFE antibody [3F1] (STJ98132)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HFE antibody, HLAH antibody,|dJ221C16.10.1 antibody|Hemochromatosis antibody|Hemochromatosis protein antibody|Hereditary hemochromatosis protein antibody|Hereditary hemochromatosis protein HLA H antibody|HFE 1 antibody|HFE antibody|HFE_HUMAN antibody|HFE1 antibody|HH antibody|High Fe antibody|HLA H antibody|HLA-H antibody|HLAH antibody|MGC:150812 antibody|MGC10379 antibody|MGC103790 antibody|MHC class I like protein HFE antibody|MVCD7 antibody|TFQTL2 antibody|Anti-HFE antibody (ab176123)
SCBT cat No: sc-18810|

 

Name

HFE Monoclonal Antibody

Catalogue No.

STJ98132

Reactivity

Human

Specificity

HFE Monoclonal Antibody detects endogenous levels of HFE protein.

Immunogen

Purified recombinant fragment of human HFE expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

HFE Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

HFE Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Hereditary hemochromatosis protein antibody, HLA-H antibody

Database links

Human UniProt/Swiss-Prot:Q30201;Mouse UniPort/Swiss-Prot: P70387;Rat UniProt/Swiss-Port: Q9R105;Human Entrez Gene: 3077;Mouse Entrez Gene: 15216;Rat Entrez Gene: Rn.42931

Protein names

Hereditary hemochromatosis protein , HLA-H

Protein function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.

Protein tissue specificity

Expressed in all tissues tested except brain.

Involvement in disease

Hemochromatosis 1 (HFE1) [MIM:235200]: A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Variegate porphyria (VP) [MIM:176200]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Variegate porphyria is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Iron overload due to HFE variants is a precipitating or exacerbating factor in variegate porphyria.; Microvascular complications of diabetes 7 (MVCD7) [MIM:612635]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the MHC class I family. / Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Lymphocyte Signaling>HFE
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize HFE Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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