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Mouse Monoclonal HFE antibody [3F1] (STJ98132)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for HFE Monoclonal Antibody.
Check alternative names for the antibodyExpand
HFE antibody, HLAH antibody,|dJ221C16.10.1 antibody|Hemochromatosis antibody|Hemochromatosis protein antibody|Hereditary hemochromatosis protein antibody|Hereditary hemochromatosis protein HLA H antibody|HFE 1 antibody|HFE antibody|HFE_HUMAN antibody|HFE1 antibody|HH antibody|High Fe antibody|HLA H antibody|HLA-H antibody|HLAH antibody|MGC:150812 antibody|MGC10379 antibody|MGC103790 antibody|MHC class I like protein HFE antibody|MVCD7 antibody|TFQTL2 antibody|Anti-HFE antibody (ab176123)
SCBT cat No: sc-18810|
HFE Monoclonal Antibody
|Catalogue No.|| |
HFE Monoclonal Antibody detects endogenous levels of HFE protein.
Purified recombinant fragment of human HFE expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
HFE Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
HFE Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Hereditary hemochromatosis protein antibody, HLA-H antibody
|Protein names|| |
Hereditary hemochromatosis protein , HLA-H
|Protein function|| |
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
|Protein tissue specificity|| |
Expressed in all tissues tested except brain.
|Involvement in disease|| |
Hemochromatosis 1 (HFE1) [MIM:235200]: A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Variegate porphyria (VP) [MIM:176200]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Variegate porphyria is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Iron overload due to HFE variants is a precipitating or exacerbating factor in variegate porphyria.; Microvascular complications of diabetes 7 (MVCD7) [MIM:612635]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the MHC class I family. / Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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