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Mouse Monoclonal HP1alpha antibody (STJ98501)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CBX5 antibody, HP1A antibody,|Antigen p25 antibody|CBX5 antibody|CBX5_HUMAN antibody|CG8409 antibody|Chromobox 5 antibody|Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody|Chromobox homolog 5 antibody|Chromobox protein homolog 5 antibody|Epididymis luminal protein 25 antibody|HEL25 antibody|Heterochromatin protein 1 alpha antibody|Heterochromatin protein 1 antibody|Heterochromatin protein 1 homolog alpha antibody|HP1 alpha antibody|HP1 alpha homolog antibody|HP1 antibody|HP1A antibody|HP1Hs alpha antibody|Su(var)205 antibody|Anti-HP1 alpha antibody – ChIP Grade (ab77256)
SCBT cat No: sc-10217|sc-10215|sc-28735|sc-10210|sc-30742|sc-130446|sc-30743|
HP1alpha Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Dog, Pig
HP1alpha Monoclonal Antibody detects endogenous levels of HP1alpha protein.
Purified recombinant human HP1alpha protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500
HP1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
HP1alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Chromobox protein homolog 5 antibody, Antigen p25 antibody, Heterochromatin protein 1 homolog alpha antibody, HP1 alpha antibody
|Protein names|| |
Chromobox protein homolog 5 , Antigen p25 , Heterochromatin protein 1 homolog alpha , HP1 alpha
|Protein function|| |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
|Protein sequence and domain|| |
Contains 2 chromo domains.
|Protein post-translational modifications|| |
Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. / Ubiquitinated.
|Protein cellular localization|| |
Nucleus / Chromosome / Chromosome > centromere
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St John’s Laboratory Ltd.
|Product type|| |
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