Mouse Monoclonal HP1alpha antibody (STJ98501)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal HP1alpha antibody (STJ98501)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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CBX5 antibody, HP1A antibody,|Antigen p25 antibody|CBX5 antibody|CBX5_HUMAN antibody|CG8409 antibody|Chromobox 5 antibody|Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody|Chromobox homolog 5 antibody|Chromobox protein homolog 5 antibody|Epididymis luminal protein 25 antibody|HEL25 antibody|Heterochromatin protein 1 alpha antibody|Heterochromatin protein 1 antibody|Heterochromatin protein 1 homolog alpha antibody|HP1 alpha antibody|HP1 alpha homolog antibody|HP1 antibody|HP1A antibody|HP1Hs alpha antibody|Su(var)205 antibody|Anti-HP1 alpha antibody – ChIP Grade (ab77256)
SCBT cat No: sc-10217|sc-10215|sc-28735|sc-10210|sc-30742|sc-130446|sc-30743|

 

Name

HP1alpha Monoclonal Antibody

Catalogue No.

STJ98501

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig

Specificity

HP1alpha Monoclonal Antibody detects endogenous levels of HP1alpha protein.

Immunogen

Purified recombinant human HP1alpha protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

HP1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

HP1alpha Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Chromobox protein homolog 5 antibody, Antigen p25 antibody, Heterochromatin protein 1 homolog alpha antibody, HP1 alpha antibody

Database links

Human UniProt/Swiss-Prot:P45973;Mouse UniPort/Swiss-Prot: Q61686;Rat UniProt/Swiss-Port: B2RYU7;Human Entrez Gene: 23468;Mouse Entrez Gene: 12419;Rat Entrez Gene: Rn.101856

Protein names

Chromobox protein homolog 5 , Antigen p25 , Heterochromatin protein 1 homolog alpha , HP1 alpha

Protein function

Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Protein sequence and domain

Contains 2 chromo domains.

Protein post-translational modifications

Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. / Ubiquitinated.

Protein cellular localization

Nucleus / Chromosome / Chromosome > centromere

Research area

All research areas>Transcription Regulators>HP1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HP1alpha Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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