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Mouse Monoclonal HXK I antibody [3A10] (STJ98151)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for HXK I Monoclonal Antibody.
Check alternative names for the antibodyExpand
HK1 antibody,|Brain form hexokinase antibody|Hexokinase 1 antibody|Hexokinase type I antibody|HK I antibody|HK1 ta antibody|HK1 tb antibody|HK1 tc antibody|HKI antibody|HXK1 antibody|Anti-pan-Hexokinase antibody [4D7] (ab58979)
SCBT cat No: sc-80978|sc-390517|sc-271865|sc-6518|sc-46695|sc-28885|
HXK I Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
HXK I Monoclonal Antibody detects endogenous levels of HXK I protein.
Purified recombinant fragment of human HXK I expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
HXK I Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
HXK I Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Hexokinase-1 antibody, Brain form hexokinase antibody, Hexokinase type I antibody, HK I antibody
|Protein names|| |
Hexokinase-1 , Brain form hexokinase , Hexokinase type I , HK I
|Protein function|| |
ATP + D-hexose = ADP + D-hexose 6-phosphate. / Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P. /
|Protein tissue specificity|| |
Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.
|Involvement in disease|| |
Hexokinase deficiency (HK deficiency) [MIM:235700]: Rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Neuropathy, hereditary motor and sensory, Russe type (HMSNR) [MIM:605285]: An autosomal recessive progressive complex peripheral neuropathy characterized by onset in the first decade of distal lower limb weakness and muscle atrophy resulting in walking difficulties. Distal impairment of the upper limbs usually occurs later, as does proximal lower limb weakness. There is distal sensory impairment, with pes cavus and areflexia. Laboratory studies suggest that it is a myelinopathy resulting in reduced nerve conduction velocities in the demyelinating range as well as a length-dependent axonopathy. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule. / Belongs to the hexokinase family. / Contains 2 hexokinase domains.
|Protein cellular localization|| |
Mitochondrion outer membrane
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St John’s Laboratory Ltd.
|Product type|| |
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