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Mouse Monoclonal IkappaB-alpha antibody (STJ98512)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
NFKBIA antibody, IKBA antibody, MAD3 antibody, NFKBI antibody,|I kappa B alpha antibody|I-kappa-B-alpha antibody|IkappaBalpha antibody|IkB-alpha antibody|IKBA antibody|IKBA_HUMAN antibody|IKBalpha antibody|MAD 3 antibody|MAD3 antibody|Major histocompatibility complex enhancer-binding protein MAD3 antibody|NF kappa B inhibitor alpha antibody|NF-kappa-B inhibitor alpha antibody|NFKBI antibody|NFKBIA antibody|Nuclear factor of kappa light chain gene enhancer in B cells antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha antibody|Anti-IKB alpha antibody [E130] (ab32518)
SCBT cat No: sc-71291|sc-52900|sc-23459|sc-23460|sc-25105|sc-71525|sc-52936|sc-23461|sc-56196|sc-56217|sc-52953|sc-71965|
IkappaB-alpha Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Pig, Sheep
IkappaB-alpha Monoclonal Antibody detects endogenous levels of IkappaB-alpha protein.
Purified recombinant human IkappaB-alpha (N-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
IkappaB-alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
IkappaB-alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
NF-kappa-B inhibitor alpha antibody, I-kappa-B-alpha antibody, IkB-alpha antibody, IkappaBalpha antibody, Major histocompatibility complex enhancer-binding protein MAD3 antibody
|Protein names|| |
NF-kappa-B inhibitor alpha , I-kappa-B-alpha , IkB-alpha , IkappaBalpha , Major histocompatibility complex enhancer-binding protein MAD3
|Protein function|| |
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
|Protein tissue specificity|| |
Induced in adherent monocytes.
|Involvement in disease|| |
Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID) [MIM:612132]: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the NF-kappa-B inhibitor family. / Contains 5 ANK repeats.
|Protein post-translational modifications|| |
Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation. / Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability. / Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-36. / Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with NFKBIA degradation and impairs subsequent NF-kappa-B activation.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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