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Mouse Monoclonal Ikaros antibody (STJ98508)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Ikaros Monoclonal Antibody.
Check alternative names for the antibodyExpand
IKZF1 antibody, IK1 antibody, IKAROS antibody, LYF1 antibody, ZNFN1A1 antibody,|CLL associated antigen KW 6 antibody|DNA-binding protein Ikaros antibody|hIk 1 antibody|Hs.54452 antibody|IK1 antibody|Ikaros (zinc finger protein) antibody|IKAROS antibody|IKAROS family zinc finger 1 (Ikaros) antibody|Ikaros family zinc finger protein 1 antibody|Ikzf1 antibody|IKZF1_HUMAN antibody|LYF1 antibody|Lymphoid transcription factor LyF-1 antibody|PRO0758 antibody|Zinc finger protein subfamily 1A 1 (Ikaros) antibody|Zinc finger protein subfamily 1A 1 antibody|Zinc finger protein, subfamily 1A, member 1 antibody|ZNFN1A1 antibody|Anti-Ikaros antibody (ab26083)
SCBT cat No: sc-398265|sc-9861|sc-13039|sc-9859|
Ikaros Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Dog
Ikaros Monoclonal Antibody detects endogenous levels of Ikaros protein.
Purified recombinant human Ikaros (C-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
Ikaros Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Ikaros Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
DNA-binding protein Ikaros antibody, Ikaros family zinc finger protein 1 antibody, Lymphoid transcription factor LyF-1 antibody
|Protein names|| |
DNA-binding protein Ikaros , Ikaros family zinc finger protein 1 , Lymphoid transcription factor LyF-1
|Protein function|| |
Transcription regulator of hematopoietic cell differentiation . Binds gamma-satellite DNA . Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms .
|Protein tissue specificity|| |
Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
|Involvement in disease|| |
Note: Defects in IKZF1 are frequent occurrences (28.6%) in acute lymphoblasic leukemia (ALL). Such alterations or deletions lead to poor prognosis for ALL.; Note: Chromosomal aberrations involving IKZF1 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;7)(q27;p12), with BCL6.; Immunodeficiency, common variable, 13 (CVID13) [MIM:616873]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. CVID13 is an autosomal dominant disease associated with a striking decrease in B-cell numbers. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin. / The C-terminal zinc-finger domain is required for dimerization. / Belongs to the Ikaros C2H2-type zinc-finger protein family. / Contains 6 C2H2-type zinc fingers.
|Protein post-translational modifications|| |
Phosphorylation controls cell-cycle progression from late G1 stage to S stage. Hyperphosphorylated during G2/M phase. Dephosphorylated state during late G1 phase. Phosphorylation on Thr-140 is required for DNA and pericentromeric location during mitosis. CK2 is the main kinase, in vitro. GSK3 and CDK may also contribute to phosphorylation of the C-terminal serine and threonine residues. Phosphorylation on these C-terminal residues reduces the DNA-binding ability. Phosphorylation/dephosphorylation events on Ser-13 and Ser-295 regulate TDT expression during thymocyte differentiation. Dephosphorylation by protein phosphatase 1 regulates stability and pericentromeric heterochromatin location. Phosphorylated in both lymphoid and non-lymphoid tissues (By similarity). Phosphorylation at Ser-361 and Ser-364 downstream of SYK induces nuclear translocation. / Sumoylated. Simulataneous sumoylation on the 2 sites results in a loss of both HDAC-dependent and HDAC-independent repression. Has no effect on pericentromeric heterochromatin location. Desumoylated by SENP1 (By similarity). / Polyubiquitinated.
|Protein cellular localization|| |
Nucleus / Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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