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Mouse Monoclonal IKKepsilon antibody [6B4B5] (STJ98166)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
IKBKE antibody, IKKE antibody, IKKI antibody, KIAA0151 antibody,|I kappa B kinase epsilon antibody|IKK-E antibody|IKK-epsilon antibody|IKK-i antibody|IKKE antibody|IKKE_HUMAN antibody|IKKepsilon antibody|IKKI antibody|Inducible I kappa B kinase antibody|Inducible I kappa-B kinase antibody|Inducible IkappaB kinase antibody|Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon antibody|Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, epsilon antibody|Inhibitor of nuclear factor kappa-B kinase subunit epsilon antibody|KIAA0151 antibody|MGC125294 antibody|MGC125295 antibody|MGC125297 antibody|Anti-IKKi/IKKe antibody (ab7891)
SCBT cat No: sc-101430|sc-52931|sc-376114|sc-365830|sc-374546|sc-10760|
IKKepsilon Monoclonal Antibody
|Catalogue No.|| |
IKKepsilon Monoclonal Antibody detects endogenous levels of IKKepsilon protein.
Purified recombinant fragment of IKKepsilon (aa1-257) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
IKKepsilon Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
IKKepsilon Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Inhibitor of nuclear factor kappa-B kinase subunit epsilon antibody, I-kappa-B kinase epsilon antibody, IKK-E antibody, IKK-epsilon antibody, IkBKE antibody, Inducible I kappa-B kinase antibody, IKK-i antibody
|Protein names|| |
Inhibitor of nuclear factor kappa-B kinase subunit epsilon , I-kappa-B kinase epsilon , IKK-E , IKK-epsilon , IkBKE , Inducible I kappa-B kinase , IKK-i
|Protein function|| |
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at ‘Ser-708’. Phosphorylation of STAT1 at ‘Ser-708’ seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. / ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
|Protein tissue specificity|| |
Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction with DDX3X. Phosphorylated at Thr-501 upon IFN activation. / Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1. / ‘Lys-63’-linked polyubiquitinated at Lys-30 and Lys-401 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Nucleus > PML body
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St John’s Laboratory Ltd.
|Product type|| |
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