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Mouse Monoclonal IRAK-4 antibody [2H9] (STJ98182)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for IRAK-4 Monoclonal Antibody.
Check alternative names for the antibodyExpand
SCBT cat No: To be updated
IRAK-4 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
IRAK-4 Monoclonal Antibody detects endogenous levels of IRAK-4 protein.
Purified recombinant fragment of human IRAK-4 expressed in E Coli
WB, IHC, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
IRAK-4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
IRAK-4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Interleukin-1 receptor-associated kinase 4 antibody, IRAK-4 antibody, Renal carcinoma antigen NY-REN-64 antibody
|Protein names|| |
Interleukin-1 receptor-associated kinase 4 , IRAK-4 , Renal carcinoma antigen NY-REN-64
|Protein function|| |
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways . Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / 650 µM for ATP (at pH 7.5) / 1100 µM for substrate (at pH 7.5)
|Involvement in disease|| |
Recurrent isolated invasive pneumococcal disease 1 (IPD1) [MIM:610799]: Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. . Note: The disease is caused by mutations affecting the gene represented in this entry.; IRAK4 deficiency (IRAK4D) [MIM:607676]: Causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. / Contains 1 death domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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