Mouse Monoclonal IRAK-4 antibody [2H9] (STJ98182)

$379.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IHC, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal IRAK-4 antibody [2H9] (STJ98182)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for IRAK-4 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

IRAK4 antibody,||
SCBT cat No: To be updated

 

Name

IRAK-4 Monoclonal Antibody

Catalogue No.

STJ98182

Reactivity

Human, Mouse, Monkey

Specificity

IRAK-4 Monoclonal Antibody detects endogenous levels of IRAK-4 protein.

Immunogen

Purified recombinant fragment of human IRAK-4 expressed in E Coli

Host

Mouse

Applications

WB, IHC, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

IRAK-4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

IRAK-4 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Interleukin-1 receptor-associated kinase 4 antibody, IRAK-4 antibody, Renal carcinoma antigen NY-REN-64 antibody

Database links

Human UniProt/Swiss-Prot:Q8TDF7;Human Entrez Gene: 51135;

Protein names

Interleukin-1 receptor-associated kinase 4 , IRAK-4 , Renal carcinoma antigen NY-REN-64

Protein function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways . Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / 650 µM for ATP (at pH 7.5) / 1100 µM for substrate (at pH 7.5)

Involvement in disease

Recurrent isolated invasive pneumococcal disease 1 (IPD1) [MIM:610799]: Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. . Note: The disease is caused by mutations affecting the gene represented in this entry.; IRAK4 deficiency (IRAK4D) [MIM:607676]: Causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. / Contains 1 death domain. / Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated.

Protein cellular localization

Cytoplasm

Research area

All research areas>Kinases and Phosphatases>IRAK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize IRAK-4 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!