Mouse Monoclonal IRE1alpha antibody [9F2] (STJ98183)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal IRE1alpha antibody [9F2] (STJ98183)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ERN1 antibody, IRE1 antibody,||
SCBT cat No: To be updated

 

Name

IRE1alpha Monoclonal Antibody

Catalogue No.

STJ98183

Reactivity

Human

Specificity

IRE1alpha Monoclonal Antibody detects endogenous levels of IRE1alpha protein.

Immunogen

Purified recombinant fragment of human IRE1alpha (aa282-433) expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

IRE1alpha Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

IRE1alpha Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Serine/threonine-protein kinase/endoribonuclease IRE1 antibody, Endoplasmic reticulum-to-nucleus signaling 1 antibody, Inositol-requiring protein 1 antibody, hIRE1p antibody, Ire1-alpha antibody, IRE1a antibody

Database links

Human UniProt/Swiss-Prot:O75460;Mouse UniPort/Swiss-Prot: Q9EQY0;Rat UniProt/Swiss-Port: F1LSY7;Human Entrez Gene: 2081;Mouse Entrez Gene: 78943;Rat Entrez Gene: Rn.226435

Protein names

Serine/threonine-protein kinase/endoribonuclease IRE1 , Endoplasmic reticulum-to-nucleus signaling 1 , Inositol-requiring protein 1 , hIRE1p , Ire1-alpha , IRE1a

Protein function

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.

Protein tissue specificity

Ubiquitously expressed. High levels observed in pancreatic tissue.

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. / Contains 1 KEN domain. / Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. / ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.

Protein cellular localization

Endoplasmic reticulum membrane / Single-pass type I membrane protein

Research area

All research areas>Signaling Intermediates>IRE1 alpha
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize IRE1alpha Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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