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Mouse Monoclonal IRE1alpha antibody [9F2] (STJ98183)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for IRE1alpha Monoclonal Antibody.
Check alternative names for the antibodyExpand
ERN1 antibody, IRE1 antibody,||
SCBT cat No: To be updated
IRE1alpha Monoclonal Antibody
|Catalogue No.|| |
IRE1alpha Monoclonal Antibody detects endogenous levels of IRE1alpha protein.
Purified recombinant fragment of human IRE1alpha (aa282-433) expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
IRE1alpha Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
IRE1alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein kinase/endoribonuclease IRE1 antibody, Endoplasmic reticulum-to-nucleus signaling 1 antibody, Inositol-requiring protein 1 antibody, hIRE1p antibody, Ire1-alpha antibody, IRE1a antibody
|Protein names|| |
Serine/threonine-protein kinase/endoribonuclease IRE1 , Endoplasmic reticulum-to-nucleus signaling 1 , Inositol-requiring protein 1 , hIRE1p , Ire1-alpha , IRE1a
|Protein function|| |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.
|Protein tissue specificity|| |
Ubiquitously expressed. High levels observed in pancreatic tissue.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. / Contains 1 KEN domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated. / ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.
|Protein cellular localization|| |
Endoplasmic reticulum membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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