Mouse Monoclonal JMJD2A antibody [5H1] (STJ98191)


Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal JMJD2A antibody [5H1] (STJ98191)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


KDM4A antibody, JHDM3A antibody, JMJD2 antibody, JMJD2A antibody, KIAA0677 antibody,|JHDM3A antibody|JmjC domain containing histone demethylation protein 3A antibody|JmjC domain-containing histone demethylation protein 3A antibody|JMJD2 antibody|JMJD2A antibody|jumonji C domain containing histone demethylase 3A antibody|Jumonji domain containing 2 antibody|Jumonji domain containing 2A antibody|Jumonji domain containing protein 2A antibody|Jumonji domain-containing protein 2A antibody|KDM4A antibody|KDM4A_HUMAN antibody|KIAA0677 antibody|Lysine (K) specific demethylase 4A antibody|Lysine-specific demethylase 4A antibody|TDRD14A antibody|Tudor domain containing 14A antibody|Anti-KDM4A / JHDM3A / JMJD2A antibody – ChIP Grade (ab24545)
SCBT cat No: sc-81302|sc-271210|sc-135065|sc-373850|sc-54624|



JMJD2A Monoclonal Antibody

Catalogue No.





JMJD2A Monoclonal Antibody detects endogenous levels of JMJD2A protein.


Purified recombinant fragment of human JMJD2A expressed in E Coli





Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000








JMJD2A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


JMJD2A Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Lysine-specific demethylase 4A antibody, JmjC domain-containing histone demethylation protein 3A antibody, Jumonji domain-containing protein 2A antibody

Database links

Human UniProt/Swiss-Prot:O75164;Mouse UniPort/Swiss-Prot: Q8BW72;Rat UniProt/Swiss-Port: D4A2N4;Human Entrez Gene: 9682;Mouse Entrez Gene: 230674;Rat Entrez Gene: Rn.233730

Protein names

Lysine-specific demethylase 4A , JmjC domain-containing histone demethylation protein 3A , Jumonji domain-containing protein 2A

Protein function

Histone demethylase that specifically demethylates ‘Lys-9’ and ‘Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-4’, H3 ‘Lys-27’ nor H4 ‘Lys-20’. Demethylates trimethylated H3 ‘Lys-9’ and H3 ‘Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. / Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. / Fe2+

Protein tissue specificity


Protein sequence and domain

The 2 Tudor domains recognize and bind methylated histone H3 ‘Lys-4’ residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 ‘Lys-4’ (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 ‘Lys-9’ (H3K9me3), di- and trimethylated H4 ‘Lys-20’ (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1. / Belongs to the JHDM3 histone demethylase family. / Contains 1 JmjC domain. / Contains 1 JmjN domain. / Contains 2 PHD-type zinc fingers. / Contains 2 Tudor domains.

Protein post-translational modifications

Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.

Protein cellular localization


Research area

All research areas>Transcription Regulators>JMJD
(View all antibody categories related to Transcription Regulators)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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