Mouse Monoclonal JMJD2A antibody [5H1] (STJ98191)

$379.00

Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal JMJD2A antibody [5H1] (STJ98191)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for JMJD2A Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

KDM4A antibody, JHDM3A antibody, JMJD2 antibody, JMJD2A antibody, KIAA0677 antibody,|JHDM3A antibody|JmjC domain containing histone demethylation protein 3A antibody|JmjC domain-containing histone demethylation protein 3A antibody|JMJD2 antibody|JMJD2A antibody|jumonji C domain containing histone demethylase 3A antibody|Jumonji domain containing 2 antibody|Jumonji domain containing 2A antibody|Jumonji domain containing protein 2A antibody|Jumonji domain-containing protein 2A antibody|KDM4A antibody|KDM4A_HUMAN antibody|KIAA0677 antibody|Lysine (K) specific demethylase 4A antibody|Lysine-specific demethylase 4A antibody|TDRD14A antibody|Tudor domain containing 14A antibody|Anti-KDM4A / JHDM3A / JMJD2A antibody – ChIP Grade (ab24545)
SCBT cat No: sc-81302|sc-271210|sc-135065|sc-373850|sc-54624|

 

Name

JMJD2A Monoclonal Antibody

Catalogue No.

STJ98191

Reactivity

Human

Specificity

JMJD2A Monoclonal Antibody detects endogenous levels of JMJD2A protein.

Immunogen

Purified recombinant fragment of human JMJD2A expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

JMJD2A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

JMJD2A Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Lysine-specific demethylase 4A antibody, JmjC domain-containing histone demethylation protein 3A antibody, Jumonji domain-containing protein 2A antibody

Database links

Human UniProt/Swiss-Prot:O75164;Mouse UniPort/Swiss-Prot: Q8BW72;Rat UniProt/Swiss-Port: D4A2N4;Human Entrez Gene: 9682;Mouse Entrez Gene: 230674;Rat Entrez Gene: Rn.233730

Protein names

Lysine-specific demethylase 4A , JmjC domain-containing histone demethylation protein 3A , Jumonji domain-containing protein 2A

Protein function

Histone demethylase that specifically demethylates ‘Lys-9’ and ‘Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-4’, H3 ‘Lys-27’ nor H4 ‘Lys-20’. Demethylates trimethylated H3 ‘Lys-9’ and H3 ‘Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. / Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. / Fe2+

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The 2 Tudor domains recognize and bind methylated histone H3 ‘Lys-4’ residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 ‘Lys-4’ (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 ‘Lys-9’ (H3K9me3), di- and trimethylated H4 ‘Lys-20’ (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1. / Belongs to the JHDM3 histone demethylase family. / Contains 1 JmjC domain. / Contains 1 JmjN domain. / Contains 2 PHD-type zinc fingers. / Contains 2 Tudor domains.

Protein post-translational modifications

Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>JMJD
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize JMJD2A Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!