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Mouse Monoclonal JMJD2A antibody [5H1] (STJ98191)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
KDM4A antibody, JHDM3A antibody, JMJD2 antibody, JMJD2A antibody, KIAA0677 antibody,|JHDM3A antibody|JmjC domain containing histone demethylation protein 3A antibody|JmjC domain-containing histone demethylation protein 3A antibody|JMJD2 antibody|JMJD2A antibody|jumonji C domain containing histone demethylase 3A antibody|Jumonji domain containing 2 antibody|Jumonji domain containing 2A antibody|Jumonji domain containing protein 2A antibody|Jumonji domain-containing protein 2A antibody|KDM4A antibody|KDM4A_HUMAN antibody|KIAA0677 antibody|Lysine (K) specific demethylase 4A antibody|Lysine-specific demethylase 4A antibody|TDRD14A antibody|Tudor domain containing 14A antibody|Anti-KDM4A / JHDM3A / JMJD2A antibody – ChIP Grade (ab24545)
SCBT cat No: sc-81302|sc-271210|sc-135065|sc-373850|sc-54624|
JMJD2A Monoclonal Antibody
|Catalogue No.|| |
JMJD2A Monoclonal Antibody detects endogenous levels of JMJD2A protein.
Purified recombinant fragment of human JMJD2A expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
JMJD2A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
JMJD2A Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Lysine-specific demethylase 4A antibody, JmjC domain-containing histone demethylation protein 3A antibody, Jumonji domain-containing protein 2A antibody
|Protein names|| |
Lysine-specific demethylase 4A , JmjC domain-containing histone demethylation protein 3A , Jumonji domain-containing protein 2A
|Protein function|| |
Histone demethylase that specifically demethylates ‘Lys-9’ and ‘Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-4’, H3 ‘Lys-27’ nor H4 ‘Lys-20’. Demethylates trimethylated H3 ‘Lys-9’ and H3 ‘Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. / Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. / Fe2+
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The 2 Tudor domains recognize and bind methylated histone H3 ‘Lys-4’ residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 ‘Lys-4’ (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 ‘Lys-9’ (H3K9me3), di- and trimethylated H4 ‘Lys-20’ (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1. / Belongs to the JHDM3 histone demethylase family. / Contains 1 JmjC domain. / Contains 1 JmjN domain. / Contains 2 PHD-type zinc fingers. / Contains 2 Tudor domains.
|Protein post-translational modifications|| |
Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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