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Mouse Monoclonal JNK3 antibody [10E4A4] (STJ98192)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MAPK10 antibody, JNK3 antibody, JNK3A antibody, PRKM10 antibody, SAPK1B antibody,|JNK 46 antibody|JNK 55 antibody|MAPK10 antibody|MAPK8 antibody|MAPK9 antibody|Mitogen-activated protein kinase 10 antibody|Mitogen-activated protein kinase 8 antibody|Mitogen-activated protein kinase 9 antibody|PRKM10 antibody|PRKM8 antibody|PRKM9 antibody|SAPK antibody|SAPK1 antibody|SAPK1b antibody|Phospho anti-JNK1 + JNK2 + JNK3 (T183+T183+T221) antibody [EPR5693] (ab124956)
SCBT cat No: sc-130075|
JNK3 Monoclonal Antibody
|Catalogue No.|| |
JNK3 Monoclonal Antibody detects endogenous levels of JNK3 protein.
Purified recombinant fragment of human JNK3 (aa28-233) expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
JNK3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
JNK3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Mitogen-activated protein kinase 10 antibody, MAP kinase 10 antibody, MAPK 10 antibody, MAP kinase p49 3F12 antibody, Stress-activated protein kinase 1b antibody, SAPK1b antibody, Stress-activated protein kinase JNK3 antibody, c-Jun N-terminal kinase 3 antibody
|Protein names|| |
Mitogen-activated protein kinase 10 , MAP kinase 10 , MAPK 10 , MAP kinase p49 3F12 , Stress-activated protein kinase 1b , SAPK1b , Stress-activated protein kinase JNK3 , c-Jun N-terminal kinase 3
|Protein function|| |
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock . / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.
|Protein tissue specificity|| |
Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
|Involvement in disease|| |
Note: A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. .
|Protein sequence and domain|| |
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. / Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro. / Palmitoylation regulates subcellular location and axonal development.
|Protein cellular localization|| |
Cytoplasm / Membrane / Lipid-anchor / Nucleus / Mitochondrion
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St John’s Laboratory Ltd.
|Product type|| |
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