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Mouse Monoclonal KLF15 antibody [2G8] (STJ98198)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for KLF15 Monoclonal Antibody.
Check alternative names for the antibodyExpand
KLF15 antibody, KKLF antibody,|Kidney enriched Kruppel like factor antibody|Kidney-enriched krueppel-like factor antibody|KKLF antibody|KKLF protein antibody|KLF 15 antibody|KLF15 antibody|KLF15_HUMAN antibody|Krueppel-like factor 15 antibody|Kruppel like factor 15 antibody|Anti-KLF15 antibody (ab2647)
SCBT cat No: sc-393627|sc-271675|sc-34826|sc-367391|sc-34827|
KLF15 Monoclonal Antibody
|Catalogue No.|| |
KLF15 Monoclonal Antibody detects endogenous levels of KLF15 protein.
Purified recombinant fragment of human KLF15 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
KLF15 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
KLF15 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Krueppel-like factor 15 antibody, Kidney-enriched krueppel-like factor antibody
|Protein names|| |
Krueppel-like factor 15 , Kidney-enriched krueppel-like factor
|Protein function|| |
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
|Protein tissue specificity|| |
Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
|Involvement in disease|| |
Note: KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). .
|Protein sequence and domain|| |
Belongs to the Sp1 C2H2-type zinc-finger protein family. / Contains 3 C2H2-type zinc fingers.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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