Mouse Monoclonal KLF15 antibody [2G8] (STJ98198)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal KLF15 antibody [2G8] (STJ98198)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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KLF15 antibody, KKLF antibody,|Kidney enriched Kruppel like factor antibody|Kidney-enriched krueppel-like factor antibody|KKLF antibody|KKLF protein antibody|KLF 15 antibody|KLF15 antibody|KLF15_HUMAN antibody|Krueppel-like factor 15 antibody|Kruppel like factor 15 antibody|Anti-KLF15 antibody (ab2647)
SCBT cat No: sc-393627|sc-271675|sc-34826|sc-367391|sc-34827|

 

Name

KLF15 Monoclonal Antibody

Catalogue No.

STJ98198

Reactivity

Human

Specificity

KLF15 Monoclonal Antibody detects endogenous levels of KLF15 protein.

Immunogen

Purified recombinant fragment of human KLF15 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

KLF15 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

KLF15 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Krueppel-like factor 15 antibody, Kidney-enriched krueppel-like factor antibody

Database links

Human UniProt/Swiss-Prot:Q9UIH9;Mouse UniPort/Swiss-Prot: Q9EPW2;Rat UniProt/Swiss-Port: Q9WTQ3;Human Entrez Gene: 28999;Mouse Entrez Gene: 66277;Rat Entrez Gene: Rn.22556

Protein names

Krueppel-like factor 15 , Kidney-enriched krueppel-like factor

Protein function

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

Protein tissue specificity

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.

Involvement in disease

Note: KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). .

Protein sequence and domain

Belongs to the Sp1 C2H2-type zinc-finger protein family. / Contains 3 C2H2-type zinc fingers.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>KLF15
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize KLF15 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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