Mouse Monoclonal KLHL12 antibody [2G2] (STJ98202)


Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal KLHL12 antibody [2G2] (STJ98202)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody


KLHL12 antibody, C3IP1 antibody,|C3IP1 antibody|CUL3 interacting protein 1 antibody|CUL3-interacting protein 1 antibody|DKIR antibody|DKIR homolog antibody|FLJ27152 antibody|hDKIR antibody|Kelch like 12 (Drosophila) antibody|Kelch like 12 antibody|Kelch like 12 variant antibody|Kelch like protein 12 antibody|Kelch like protein C3IP1 antibody|kelch-like family member 12 antibody|Kelch-like protein 12 antibody|KLH12_HUMAN antibody|KLHL 12 antibody|klhl12 antibody|OTTHUMP00000038799 antibody|Anti-C3IP1 antibody (ab203880)
SCBT cat No: sc-514874|



KLHL12 Monoclonal Antibody

Catalogue No.





KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein.


Purified recombinant fragment of human KLHL12 expressed in E Coli





Recommended dilution

WB 1:500-1:2000; ELISA 1:10000








KLHL12 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


KLHL12 Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Kelch-like protein 12 antibody, CUL3-interacting protein 1 antibody, DKIR homolog antibody, hDKIR antibody

Database links

Human UniProt/Swiss-Prot:Q53G59;Mouse UniPort/Swiss-Prot: Q8BZM0;Rat UniProt/Swiss-Port: Q8R2H4;Human Entrez Gene: 59349;Mouse Entrez Gene: 240756;Rat Entrez Gene: Rn.15513

Protein names

Kelch-like protein 12 , CUL3-interacting protein 1 , DKIR homolog , hDKIR

Protein function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. /

Protein tissue specificity

Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.

Protein sequence and domain

The BTB domain is required for interaction with CUL3. / Contains 1 BACK (BTB/Kelch associated) domain. / Contains 1 BTB (POZ) domain. / Contains 6 Kelch repeats.

Protein cellular localization

Cytoplasmic vesicle > COPII-coated vesicle

Research area

All research areas>Signaling Intermediates>KLHL12
(View all antibody categories related to Signaling Intermediates)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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