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Mouse Monoclonal KLHL12 antibody [2G2] (STJ98202)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
KLHL12 antibody, C3IP1 antibody,|C3IP1 antibody|CUL3 interacting protein 1 antibody|CUL3-interacting protein 1 antibody|DKIR antibody|DKIR homolog antibody|FLJ27152 antibody|hDKIR antibody|Kelch like 12 (Drosophila) antibody|Kelch like 12 antibody|Kelch like 12 variant antibody|Kelch like protein 12 antibody|Kelch like protein C3IP1 antibody|kelch-like family member 12 antibody|Kelch-like protein 12 antibody|KLH12_HUMAN antibody|KLHL 12 antibody|klhl12 antibody|OTTHUMP00000038799 antibody|Anti-C3IP1 antibody (ab203880)
SCBT cat No: sc-514874|
KLHL12 Monoclonal Antibody
|Catalogue No.|| |
KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein.
Purified recombinant fragment of human KLHL12 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
KLHL12 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
KLHL12 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Kelch-like protein 12 antibody, CUL3-interacting protein 1 antibody, DKIR homolog antibody, hDKIR antibody
|Protein names|| |
Kelch-like protein 12 , CUL3-interacting protein 1 , DKIR homolog , hDKIR
|Protein function|| |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. /
|Protein tissue specificity|| |
Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
|Protein sequence and domain|| |
The BTB domain is required for interaction with CUL3. / Contains 1 BACK (BTB/Kelch associated) domain. / Contains 1 BTB (POZ) domain. / Contains 6 Kelch repeats.
|Protein cellular localization|| |
Cytoplasmic vesicle > COPII-coated vesicle
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St John’s Laboratory Ltd.
|Product type|| |
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