Mouse Monoclonal KLHL22 antibody [7B10] (STJ98205)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal KLHL22 antibody [7B10] (STJ98205)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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KLHL22 antibody,|2610318I18Rik antibody|kelch-like 22 antibody|kelch-like family member 22 antibody|Kelch-like protein 22 antibody|KELCHL antibody|KLH22_HUMAN antibody|Klhl22 antibody|RGD1306288 antibody|Anti-KLHL22 antibody (ab172898)
SCBT cat No: To be updated

 

Name

KLHL22 Monoclonal Antibody

Catalogue No.

STJ98205

Reactivity

Human

Specificity

KLHL22 Monoclonal Antibody detects endogenous levels of KLHL22 protein.

Immunogen

Purified recombinant fragment of human KLHL22 expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

KLHL22 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

KLHL22 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Kelch-like protein 22 antibody

Database links

Human UniProt/Swiss-Prot:Q53GT1;Mouse UniPort/Swiss-Prot: Q99JN2;Rat UniProt/Swiss-Port: D3ZZC3;Human Entrez Gene: 84861;Mouse Entrez Gene: 224023;Rat Entrez Gene: Rn.23143

Protein names

Kelch-like protein 22

Protein function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. /

Protein sequence and domain

Contains 1 BTB (POZ) domain. / Contains 6 Kelch repeats.

Protein cellular localization

Cytoplasm / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > spindle

Research area

All research areas>Signaling Intermediates>KLHL
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize KLHL22 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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