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Mouse Monoclonal KLHL22 antibody [7B10] (STJ98205)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
KLHL22 antibody,|2610318I18Rik antibody|kelch-like 22 antibody|kelch-like family member 22 antibody|Kelch-like protein 22 antibody|KELCHL antibody|KLH22_HUMAN antibody|Klhl22 antibody|RGD1306288 antibody|Anti-KLHL22 antibody (ab172898)
SCBT cat No: To be updated
KLHL22 Monoclonal Antibody
|Catalogue No.|| |
KLHL22 Monoclonal Antibody detects endogenous levels of KLHL22 protein.
Purified recombinant fragment of human KLHL22 expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
KLHL22 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
KLHL22 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Kelch-like protein 22 antibody
|Protein names|| |
Kelch-like protein 22
|Protein function|| |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. /
|Protein sequence and domain|| |
Contains 1 BTB (POZ) domain. / Contains 6 Kelch repeats.
|Protein cellular localization|| |
Cytoplasm / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > spindle
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St John’s Laboratory Ltd.
|Product type|| |
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