Mouse Monoclonal LAL antibody [9G7F12; 7G6D7] (STJ98212)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal LAL antibody [9G7F12; 7G6D7] (STJ98212)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LIPA antibody,|Acid cholesteryl ester hydrolase antibody|CESD antibody|cholesterol ester hydrolase antibody|cholesterol ester storage disease antibody|Cholesteryl esterase antibody|Hydrolase deficiency antibody|LAL antibody|LAL deficiency cholesterol ester antibody|LICH_HUMAN antibody|lipA antibody|LIPA deficiency antibody|Lipase A antibody|lipase A, lysosomal acid, cholesterol esterase antibody|lysosomal acid lipase antibody|lysosomal acid lipase deficiency antibody|Lysosomal acid lipase/cholesteryl ester hydrolase antibody|Sterol esterase antibody|Anti-Lysosomal acid lipase antibody (ab73445)
SCBT cat No: sc-58374|

 

Name

LAL Monoclonal Antibody

Catalogue No.

STJ98212

Reactivity

Human

Specificity

LAL Monoclonal Antibody detects endogenous levels of LAL protein.

Immunogen

Purified recombinant fragment of LAL expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

LAL Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

LAL Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Lysosomal acid lipase/cholesteryl ester hydrolase antibody, Acid cholesteryl ester hydrolase antibody, LAL antibody, Cholesteryl esterase antibody, Lipase A antibody, Sterol esterase antibody

Database links

Human UniProt/Swiss-Prot:P38571;Mouse UniPort/Swiss-Prot: Q9Z0M5;Rat UniProt/Swiss-Port: Q6IMY6;Human Entrez Gene: 3988;Mouse Entrez Gene: 16889;Rat Entrez Gene: Rn.48656

Protein names

Lysosomal acid lipase/cholesteryl ester hydrolase , Acid cholesteryl ester hydrolase , LAL , Cholesteryl esterase , Lipase A , Sterol esterase

Protein function

Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. / A steryl ester + H2O = a sterol + a fatty acid.

Involvement in disease

Wolman disease (WOD) [MIM:278000]: A severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WD occurs in infancy and is nearly always fatal before the age of 1 year. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cholesteryl ester storage disease (CESD) [MIM:278000]: A mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the AB hydrolase superfamily. Lipase family.

Protein cellular localization

Lysosome

Research area

All research areas>Synthesis and Degradation>LAL
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize LAL Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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