Mouse Monoclonal Lamin B1 antibody [7C11] (STJ96938)

$99.00$319.00

Reactivity: Human, Rat, Mouse
Applications: WB, IHC, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Lamin B1 antibody [7C11]

(STJ96938)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IP

Recommended dilution: WB 1:2000-5000; IP 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Lamin B1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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LMNB1 antibody, LMN2 antibody, LMNB antibody,|ADLD antibody|CMD1A antibody|CMT2B1 antibody|Lamin A/C antibody|Lamin B1 antibody|Lamin B2 antibody|LMN2 antibody|LMNA antibody|LMNB1 antibody|LMNB2 antibody|Anti-Lamin B1 antibody – Nuclear Envelope Marker (ab16048)
SCBT cat No: sc-6216|sc-6217|sc-160482|sc-56143|sc-56144|sc-377000|sc-374015|sc-365214|sc-365962|sc-377001|sc-373918|sc-20682|sc-30264|

Name

Lamin B1 Monoclonal Antibody

Catalogue No.

STJ96938

Reactivity

Human, Rat, Mouse

Specificity

The antibody detects endogenous Lamin B1 protein.

Immunogen

Recombinant Protein

Host

Mouse

Applications

WB, IP

Recommended dilution

WB 1:2000-5000; IP 1:200

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Lamin B1 Antibody was tube-contained. PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Purification

Lamin B1 Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Lamin-B1 antibody

Database links

Human UniProt/Swiss-Prot:P20700;Mouse UniPort/Swiss-Prot: P14733;Rat UniProt/Swiss-Port: P70615;Human Entrez Gene: 4001;Mouse Entrez Gene: 16906;Rat Entrez Gene: Rn.11362

Protein names

Lamin-B1

Protein function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Involvement in disease

Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD) [MIM:169500]: A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the intermediate filament family. / Contains 1 LTD domain.

Protein post-translational modifications

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Protein cellular localization

Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side

Research area

All research areas>Tumor Suppressor/Apoptosis>Lamin
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Lamin B1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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Immunofluorescence analysis of Human appendix tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human appendix tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human lung cancer tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human lung cancer tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human stomach cancer tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human stomach cancer tissue

1: Lamin B1 Monoclonal Antibody(7C11)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunohistochemical analysis of paraffin embedded Human uterus tissue

1: Lamin B1 Monoclonal Antibody(7C11) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human colon tissue

1: Lamin B1 Monoclonal Antibody(7C11) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human appendix tissue

1: Lamin B1 Monoclonal Antibody(7C11) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.


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