Mouse Monoclonal LEDGF antibody [6E4] (STJ98216)

$379.00

Reactivity: Human, Rat, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal LEDGF antibody [6E4] (STJ98216)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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PSIP1 antibody, DFS70 antibody, LEDGF antibody, PSIP2 antibody,|CLL associated antigen KW 7 antibody|CLL-associated antigen KW-7 antibody|Dense fine speckles 70 kDa protein antibody|DFS 70 antibody|DFS70 antibody|LEDGF antibody|Lens epithelium derived growth factor antibody|Lens epithelium-derived growth factor antibody|MGC74712 antibody|p52 antibody|p75 antibody|PAIP antibody|PC4 and SFRS1 interacting protein 1 antibody|PC4 and SFRS1 interacting protein 2 antibody|PC4 and SFRS1 interacting protein antibody|PC4 and SFRS1-interacting protein antibody|PSIP 1 antibody|PSIP 2 antibody|Psip1 antibody|PSIP1_HUMAN antibody|PSIP2 antibody|Transcriptional coactivator p75/p52 antibody|Anti-PSIP1 antibody [EPR11890] (ab177159)
SCBT cat No: sc-136227|sc-101087|sc-33371|

 

Name

LEDGF Monoclonal Antibody

Catalogue No.

STJ98216

Reactivity

Human, Rat, Monkey

Specificity

LEDGF Monoclonal Antibody detects endogenous levels of LEDGF protein.

Immunogen

Purified recombinant fragment of human LEDGF expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

LEDGF Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

LEDGF Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

PC4 and SFRS1-interacting protein antibody, CLL-associated antigen KW-7 antibody, Dense fine speckles 70 kDa protein antibody, DFS 70 antibody, Lens epithelium-derived growth factor antibody, Transcriptional coactivator p75/p52 antibody

Database links

Human UniProt/Swiss-Prot:O75475;Mouse UniPort/Swiss-Prot: Q99JF8;Rat UniProt/Swiss-Port: Q812D1;Human Entrez Gene: 11168;Mouse Entrez Gene: 101739;Rat Entrez Gene: Rn.93075

Protein names

PC4 and SFRS1-interacting protein , CLL-associated antigen KW-7 , Dense fine speckles 70 kDa protein , DFS 70 , Lens epithelium-derived growth factor , Transcriptional coactivator p75/p52

Protein function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Protein tissue specificity

Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.

Involvement in disease

Note: A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4. .

Protein sequence and domain

Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain). / Belongs to the HDGF family. / Contains 1 PWWP domain.

Protein post-translational modifications

Citrullinated by PADI4.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>PSIP1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize LEDGF Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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