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Mouse Monoclonal LIN-28 antibody [6D1F9] (STJ98218)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for LIN-28 Monoclonal Antibody.
Check alternative names for the antibodyExpand
LIN28A antibody, CSDD1 antibody, LIN28 antibody, ZCCHC1 antibody,|AL024421 antibody|CSDD1 antibody|FLJ12457 antibody|Lin 28 antibody|Lin 28 homolog (C. elegans) antibody|Lin 28 homolog A (C. elegans) antibody|Lin 28 homolog A antibody|Lin 28 homolog antibody|Lin-28A antibody|Lin28 antibody|Lin28, C. elegans, homolog of, A antibody|LIN28A antibody|LN28A_HUMAN antibody|Protein lin-28 homolog A antibody|RNA binding protein lin 28 antibody|Tex17 antibody|ZCCHC1 antibody|Zinc finger CCHC domain containing 1 antibody|Zinc finger CCHC domain containing protein 1 antibody|Zinc finger CCHC domain-containing protein 1 antibody|Anti-Lin28 antibody (ab46020)
SCBT cat No: sc-293120|sc-54029|sc-374460|sc-54030|sc-67266|sc-54032|
LIN-28 Monoclonal Antibody
|Catalogue No.|| |
LIN-28 Monoclonal Antibody detects endogenous levels of LIN-28 protein.
Purified recombinant fragment of LIN-28 (aa93-209) expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
LIN-28 Antibody was tube-contained. Antibody are purified by protein G affinity chromatography. Liquid in 0.01M Phosphate buffer, pH 7.4 containing 0.03% sodium azide.
LIN-28 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Protein lin-28 homolog A antibody, Lin-28A antibody, Zinc finger CCHC domain-containing protein 1 antibody
|Protein names|| |
Protein lin-28 homolog A , Lin-28A , Zinc finger CCHC domain-containing protein 1
|Protein function|| |
Translational enhancer’ that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5′-GGAG-3′ motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs . Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (By similarity).
|Protein tissue specificity|| |
Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.
|Protein sequence and domain|| |
The CSD domain is required for function in muscle differentiation. / The CCHC zinc fingers interact with the GGAG motif at the 3′ end of let-7 miRNAs precursors, more generally they bind the 5′-NGNNG-3′ consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5′ end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members. / Belongs to the lin-28 family. / Contains 2 CCHC-type zinc fingers. / Contains 1 CSD (cold-shock) domain.
|Protein cellular localization|| |
Cytoplasm / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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