Mouse Monoclonal LMP7A antibody [1A5] (STJ98221)

$379.00

Reactivity: Human, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal LMP7A antibody [1A5] (STJ98221)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PSMB8 antibody, LMP7 antibody, PSMB5i antibody, RING10 antibody, Y2 antibody,|ALDD antibody|Proteasome subunit beta 5i antibody|Proteasome subunit beta 8 antibody|Proteasome subunit beta type 8 antibody|Proteasome subunit beta type antibody|Proteasome subunit beta type-8 antibody|Proteasome subunit beta-5i antibody|Proteasome subunit Y2 antibody|PSB8_HUMAN antibody|PSMB 8 antibody|PSMB5i antibody|PSMB8 antibody|Really interesting new gene 10 protein antibody|RING 10 antibody|RING10 antibody|Y2 antibody|Anti-Proteasome 20S LMP7 antibody (ab3329)
SCBT cat No: sc-100284|sc-365699|sc-365698|sc-374089|sc-17073|sc-17070|

 

Name

LMP7A Monoclonal Antibody

Catalogue No.

STJ98221

Reactivity

Human, Rat

Specificity

LMP7A Monoclonal Antibody detects endogenous levels of LMP7A protein.

Immunogen

Purified recombinant fragment of human LMP7A expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

LMP7A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

LMP7A Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Proteasome subunit beta type-8 antibody, Low molecular mass protein 7 antibody, Macropain subunit C13 antibody, Multicatalytic endopeptidase complex subunit C13 antibody, Proteasome component C13 antibody, Proteasome subunit beta-5i antibody, Really interesting new gene 10 protein antibody

Database links

Human UniProt/Swiss-Prot:P28062;Mouse UniPort/Swiss-Prot: P28063;Rat UniProt/Swiss-Port: P28064;Human Entrez Gene: 5696;Mouse Entrez Gene: 16913;Rat Entrez Gene: Rn.203098

Protein names

Proteasome subunit beta type-8 , Low molecular mass protein 7 , Macropain subunit C13 , Multicatalytic endopeptidase complex subunit C13 , Proteasome component C13 , Proteasome subunit beta-5i , Really interesting new gene 10 protein

Protein function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. / Cleavage of peptide bonds with very broad specificity.

Protein tissue specificity

Highly expressed in immature dendritic cells (at protein level).

Involvement in disease

Nakajo syndrome (NKJO) [MIM:256040]: An autosomal recessive autoinflammatory disorder characterized by early childhood onset of recurrent fever, joint stiffness and severe contractures of the hands and feet, and erythematous skin lesions with subsequent development of lipodystrophy and laboratory evidence of immune dysregulation. Accompanying features may include muscle weakness and atrophy, hepatosplenomegaly, and microcytic anemia. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase T1B family.

Protein post-translational modifications

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Lymphocyte Signaling>LMP
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize LMP7A Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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