Mouse Monoclonal LSD1 antibody (STJ98515)

$379.00

Reactivity: Human, Mouse, Cow, Dog, Pig
Applications: WB, IHC, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal LSD1 antibody (STJ98515)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF

Recommended dilution: WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500

Recommended protocols: check protocols

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Alternative names:

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KDM1A antibody, AOF2 antibody, KDM1 antibody, KIAA0601 antibody, LSD1 antibody,|Amine oxidase (flavin containing) domain 2 antibody|Amine oxidase, flavin containing, 2 antibody|AOF2 antibody|BHC110 antibody|BRAF35 HDAC complex protein BHC110 antibody|BRAF35-HDAC complex protein BHC110 antibody|BRAF35/HDAC complex, 110-kD subunit antibody|CPRF antibody|EC1 antibody|FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody|Flavin-containing amine oxidase domain-containing protein 2 antibody|KDM 1 antibody|KDM1 antibody|Kdm1a antibody|KDM1A_HUMAN antibody|KIAA0601 antibody|LSD 1 antibody|LSD1 antibody|Lysine (K) specific demethylase 1 antibody|Lysine (K) specific demethylase 1A antibody|Lysine demethylase 1A antibody|Lysine specific histone demethylase 1 antibody|Lysine specific histone demethylase 1A antibody|Lysine-specific demethylase 1 antibody|Lysine-specific demethylase 1A antibody|Lysine-specific histone demethylase 1A antibody|Anti-KDM1 / LSD1 antibody – ChIP Grade (ab17721)
SCBT cat No: sc-53875|sc-136174|sc-271720|sc-67272|sc-49294|

 

Name

LSD1 Monoclonal Antibody

Catalogue No.

STJ98515

Reactivity

Human, Mouse, Cow, Dog, Pig

Specificity

LSD1 Monoclonal Antibody detects endogenous levels of LSD1 protein.

Immunogen

Purified recombinant human LSD1 (N-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IHC, IF

Recommended dilution

WB 1:1000-1:2000; IHC 1:500-1:1000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

LSD1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

LSD1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Lysine-specific histone demethylase 1A antibody, BRAF35-HDAC complex protein BHC110 antibody, Flavin-containing amine oxidase domain-containing protein 2 antibody

Database links

Human UniProt/Swiss-Prot:O60341;Mouse UniPort/Swiss-Prot: Q6ZQ88;Rat UniProt/Swiss-Port: B3STT9;Human Entrez Gene: 23028;Mouse Entrez Gene: 99982;Rat Entrez Gene: Rn.203461

Protein names

Lysine-specific histone demethylase 1A , BRAF35-HDAC complex protein BHC110 , Flavin-containing amine oxidase domain-containing protein 2

Protein function

Histone demethylase that demethylates both ‘Lys-4’ (H3K4me) and ‘Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of ‘Thr-6’ of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated ‘Lys-370’ of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. / FAD / 3.0 µM for H3 monomethyl-K4 / 4.2 µM for H3 dimethyl-K4 / 3.9 µM for H3 monomethyl-K4-monomethyl-K9 / 17.5 µM for monomethyl-K4-acetyl-K9

Protein tissue specificity

Ubiquitously expressed.

Involvement in disease

Cleft palate, psychomotor retardation, and distinctive facial features (CPRF) [MIM:616728]: A syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The SWIRM domain may act as an anchor site for a histone tail. / Belongs to the flavin monoamine oxidase family. / Contains 1 SWIRM domain.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>LSD1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize LSD1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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