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Mouse Monoclonal LysRS antibody [8G12C1] (STJ98227)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
KARS antibody, KIAA0070 antibody,|CMTRIB antibody|DFNB89 antibody|EC 184.108.40.206 antibody|KARS 1 antibody|KARS 2 antibody|KARS antibody|KARS1 antibody|KARS2 antibody|KIAA0070 antibody|KRS antibody|Lysine tRNA ligase antibody|Lysine–tRNA ligase antibody|LysRS antibody|Lysyl-tRNA synthetase antibody|SYK_HUMAN antibody|Anti-Lysyl tRNA synthetase antibody (ab31532)
SCBT cat No: sc-271331|sc-393180|sc-79253|sc-393645|sc-98559|
LysRS Monoclonal Antibody
|Catalogue No.|| |
LysRS Monoclonal Antibody detects endogenous levels of LysRS protein.
Purified recombinant fragment of LysRS(aa90-174) expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
LysRS Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
LysRS Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Lysine–tRNA ligase antibody, Lysyl-tRNA synthetase antibody, LysRS antibody
|Protein names|| |
Lysine–tRNA ligase , Lysyl-tRNA synthetase , LysRS
|Protein function|| |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3(Lys), the primer for reverse transcription initiation. / ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). / Ca2+ / Up-regulated by DARS and EEF1A1, but not by AIMP2.
|Involvement in disease|| |
Charcot-Marie-Tooth disease, recessive, intermediate type, B (CMTRIB) [MIM:613641]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Deafness, autosomal recessive, 89 (DFNB89) [MIM:613916]: A form of non-syndromic deafness characterized by bilateral, prelingual, moderate to severe hearing loss affecting all frequencies. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The N-terminal domain (1-65) of the cytoplasmic isoform is a functional tRNA-binding domain (By similarity), is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. The C-terminal domain (452-597) is not required for interaction with AIMP2. / Belongs to the class-II aminoacyl-tRNA synthetase family.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Cell membrane; Peripheral membrane protein / Secreted / Mitochondrion
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St John’s Laboratory Ltd.
|Product type|| |
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