Mouse Monoclonal Mcl-1 antibody [8C6; 8C6D4B1] (STJ98232)


Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Mcl-1 antibody [8C6; 8C6D4B1] (STJ98232)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Mcl-1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody


MCL1 antibody, BCL2L3 antibody,|Myeloid cell leukemia sequence 1 isoform 1 antibody|OTTHUMP00000032794 antibody|OTTHUMP00000032795 antibody|TM antibody|Anti-MCL1 antibody [Y37] (ab32087)
SCBT cat No: sc-12756|sc-53951|sc-74436|sc-377487|sc-74437|sc-20679|sc-69841|sc-69840|sc-69839|sc-69838|sc-56152|sc-53971|sc-819|sc-56427|sc-958|



Mcl-1 Monoclonal Antibody

Catalogue No.





Mcl-1 Monoclonal Antibody detects endogenous levels of Mcl-1 protein.


Purified recombinant fragment of human MCL-1 expressed in E Coli





Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000








Mcl-1 Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.


1 mg/ml


Mcl-1 Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Induced myeloid leukemia cell differentiation protein Mcl-1 antibody, Bcl-2-like protein 3 antibody, Bcl2-L-3 antibody, Bcl-2-related protein EAT/mcl1 antibody, mcl1/EAT antibody

Database links

Human UniProt/Swiss-Prot:Q07820;Mouse UniPort/Swiss-Prot: P97287;Rat UniProt/Swiss-Port: Q9Z1P3;Human Entrez Gene: 4170;Mouse Entrez Gene: 17210;Rat Entrez Gene: Rn.129914

Protein names

Induced myeloid leukemia cell differentiation protein Mcl-1 , Bcl-2-like protein 3 , Bcl2-L-3 , Bcl-2-related protein EAT/mcl1 , mcl1/EAT

Protein function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Protein tissue specificity

Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.

Protein sequence and domain

Belongs to the Bcl-2 family.

Protein post-translational modifications

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. / Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. / Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. / Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.

Protein cellular localization

Membrane / Cytoplasm / Mitochondrion / Nucleus > nucleoplasm

Research area

All research areas>Tumor Suppressor/Apoptosis>Mcl-1
(View all antibody categories related to Tumor Suppressor/Apoptosis)


AntibodyPlus can customize Mcl-1 Antibody according to your requirement, including bulk product size,etc. Please contact AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.


St John’s Laboratory Ltd.

Product type

Primary antibody


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