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Mouse Monoclonal Mcl-1 antibody [8C6; 8C6D4B1] (STJ98232)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Mcl-1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
MCL1 antibody, BCL2L3 antibody,|Myeloid cell leukemia sequence 1 isoform 1 antibody|OTTHUMP00000032794 antibody|OTTHUMP00000032795 antibody|TM antibody|Anti-MCL1 antibody [Y37] (ab32087)
SCBT cat No: sc-12756|sc-53951|sc-74436|sc-377487|sc-74437|sc-20679|sc-69841|sc-69840|sc-69839|sc-69838|sc-56152|sc-53971|sc-819|sc-56427|sc-958|
Mcl-1 Monoclonal Antibody
|Catalogue No.|| |
Mcl-1 Monoclonal Antibody detects endogenous levels of Mcl-1 protein.
Purified recombinant fragment of human MCL-1 expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Mcl-1 Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.
Mcl-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Induced myeloid leukemia cell differentiation protein Mcl-1 antibody, Bcl-2-like protein 3 antibody, Bcl2-L-3 antibody, Bcl-2-related protein EAT/mcl1 antibody, mcl1/EAT antibody
|Protein names|| |
Induced myeloid leukemia cell differentiation protein Mcl-1 , Bcl-2-like protein 3 , Bcl2-L-3 , Bcl-2-related protein EAT/mcl1 , mcl1/EAT
|Protein function|| |
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
|Protein tissue specificity|| |
Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
|Protein sequence and domain|| |
Belongs to the Bcl-2 family.
|Protein post-translational modifications|| |
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. / Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. / Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. / Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
|Protein cellular localization|| |
Membrane / Cytoplasm / Mitochondrion / Nucleus > nucleoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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