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Mouse Monoclonal MDMX antibody [2D10F4] (STJ98235)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MDM4 antibody, MDMX antibody,|DKFZp781B1423 antibody|Mdm4 transformed 3T3 cell double minute 4 antibody|Mdm4 transformed 3T3 cell double minute 4 p53 binding protein antibody|Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse antibody|MDM4_HUMAN antibody|Mdmx protein antibody|MGC132766 antibody|Mouse double minute 4 homolog antibody|Mouse double minute 4 human homolog of p53 binding protein antibody|MRP 1 antibody|MRP1 antibody|p53 binding protein antibody|p53 BINDING PROTEIN MDM4 antibody|p53-binding protein Mdm4 antibody|Protein Mdm4 antibody|Protein Mdmx antibody|Anti-MDMX antibody [MDMX-82] (ab49993)
SCBT cat No: sc-374147|sc-14740|sc-14738|sc-365902|sc-74468|sc-74467|sc-28222|
MDMX Monoclonal Antibody
|Catalogue No.|| |
MDMX Monoclonal Antibody detects endogenous levels of MDMX protein.
Purified recombinant fragment of human MDMX expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
MDMX Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MDMX Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Protein Mdm4 antibody, Double minute 4 protein antibody, Mdm2-like p53-binding protein antibody, Protein Mdmx antibody, p53-binding protein Mdm4 antibody
|Protein names|| |
Protein Mdm4 , Double minute 4 protein , Mdm2-like p53-binding protein , Protein Mdmx , p53-binding protein Mdm4
|Protein function|| |
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
|Protein tissue specificity|| |
Expressed in all tissues tested with high levels in thymus.
|Protein sequence and domain|| |
Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2. / Belongs to the MDM2/MDM4 family. / Contains 1 RanBP2-type zinc finger. / Contains 1 RING-type zinc finger. / Contains 1 SWIB domain.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent. / Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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