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Mouse Monoclonal MEK-2 antibody [7F5] (STJ98237)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MAP2K2 antibody, MEK2 antibody, MKK2 antibody, PRKMK2 antibody,|Cardiofaciocutaneous syndrome antibody|CFC syndrome antibody|CFC4 antibody|Dual specificity mitogen activated protein kinase kinase 2 antibody|Dual specificity mitogen-activated protein kinase kinase 2 antibody|ERK activator kinase 2 antibody|FLJ26075 antibody|MAP kinase kinase 2 antibody|map2k2 antibody|MAPK / ERK kinase 2 antibody|MAPK/ERK kinase 2 antibody|MAPKK 2 antibody|MAPKK2 antibody|MEK 2 antibody|MEK2 antibody|Microtubule associated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 p45 antibody|MKK 2 antibody|MKK2 antibody|MP2K2_HUMAN antibody|OTTHUMP00000165826 antibody|OTTHUMP00000165827 antibody|PRKMK 2 antibody|PRKMK2 antibody|Anti-MEK2 antibody [Y78] (ab32517)
SCBT cat No: sc-81473|sc-136261|sc-13159|sc-525|sc-524|sc-135985|sc-81474|
MEK-2 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
MEK-2 Monoclonal Antibody detects endogenous levels of MEK-2 protein.
Purified recombinant fragment of human MEK-2 expressed in E Coli
WB, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
MEK-2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MEK-2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dual specificity mitogen-activated protein kinase kinase 2 antibody, MAP kinase kinase 2 antibody, MAPKK 2 antibody, ERK activator kinase 2 antibody, MAPK/ERK kinase 2 antibody, MEK 2 antibody
|Protein names|| |
Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2 , MAPKK 2 , ERK activator kinase 2 , MAPK/ERK kinase 2 , MEK 2
|Protein function|| |
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). / ATP + a protein = ADP + a phosphoprotein. / Mg2+
|Involvement in disease|| |
Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity). / Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
|Protein cellular localization|| |
Cytoplasm / Membrane / Peripheral membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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