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Mouse Monoclonal MEK-4 antibody [2D10D8; 4G11B2; 2D10C4; 2D10C3] (STJ98238)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, ELISA
Recommended dilution: IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MAP2K4 antibody, JNKK1 antibody, MEK4 antibody, MKK4 antibody, PRKMK4 antibody, SEK1 antibody, SERK1 antibody, SKK1 antibody,|c Jun N terminal kinase kinase 1 antibody|C-JUN N-terminal kinase kinase 1 antibody|Dual specificity mitogen activated protein kinase kinase 4 antibody|Dual specificity mitogen-activated protein kinase kinase 4 antibody|JNK Activated Kinase 1 antibody|JNK activating kinase 1 antibody|JNK-activating kinase 1 antibody|JNKK antibody|JNKK1 antibody|MAP kinase kinase 4 antibody|Map2k4 antibody|MAPK ERK kinase 4 antibody|MAPK/ERK kinase 4 antibody|MAPKK 4 antibody|MAPKK4 antibody|MEK 4 antibody|MEK4 antibody|Mitogen activated protein kinase kinase 4 antibody|MKK 4 antibody|MKK4 antibody|MP2K4_HUMAN antibody|PRKMK4 antibody|SAPK ERK kinase 1 antibody|SAPK/ERK kinase 1 antibody|SAPKK 1 antibody|SAPKK1 antibody|SEK1 antibody|SERK1 antibody|SKK1 antibody|Stress activated protein kinase kinase 1 antibody|Phospho anti-MEK4 (S80) antibody (ab39403)
SCBT cat No: sc-136314|sc-837|sc-166168|sc-376838|sc-13070|sc-964|sc-135986|sc-1287|sc-365198|
MEK-4 Monoclonal Antibody
|Catalogue No.|| |
MEK-4 Monoclonal Antibody detects endogenous levels of MEK-4 protein.
Purified recombinant fragment of MEK-4 expressed in E Coli
|Recommended dilution|| |
IHC 1:200-1:1000; ELISA 1:10000
MEK-4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MEK-4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dual specificity mitogen-activated protein kinase kinase 4 antibody, MAP kinase kinase 4 antibody, MAPKK 4 antibody, JNK-activating kinase 1 antibody, MAPK/ERK kinase 4 antibody, MEK 4 antibody, SAPK/ERK kinase 1 antibody, SEK1 antibody, Stress-activated protein kinase kinase 1 antibody, SAPK kinase 1 antibody, SAPKK-1 antibody, SAPKK1 antibody, c-Jun N-terminal kinase kinase 1 antibody, JNKK antibody
|Protein names|| |
Dual specificity mitogen-activated protein kinase kinase 4 , MAP kinase kinase 4 , MAPKK 4 , JNK-activating kinase 1 , MAPK/ERK kinase 4 , MEK 4 , SAPK/ERK kinase 1 , SEK1 , Stress-activated protein kinase kinase 1 , SAPK kinase 1 , SAPKK-1 , SAPKK1 , c-Jun N-terminal kinase kinase 1 , JNKK
|Protein function|| |
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. / ATP + a protein = ADP + a phosphoprotein. / Activated in response to a variety of cellular stresses, including UV and gamma-irradiation, heat shock, hyperosmolarity, T-cell receptor stimulation, peroxide and inflammatory cytokines. Also activated by developmental cues. MAP2K4/MKK4 is activated by the majority of MKKKs, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K7/TAK1, MAP3K10/MLK2, MAP3K11/MLK3, MAP3K12/DLK and MAP3K13/LZK.
|Protein tissue specificity|| |
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
|Protein sequence and domain|| |
The DVD domain (residues 364-387) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation. / The D domain (residues 34-52) contains a conserved docking site and is required for the binding to MAPK substrates. / Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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