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Mouse Monoclonal MerTK antibody [7E5G1] (STJ98242)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MERTK antibody, MER antibody,|c MER antibody|c mer proto oncogene tyrosine kinase antibody|c-mer antibody|cMER antibody|cmer protooncogene tyrosine kinase antibody|Eyk antibody|MER antibody|MER receptor tyrosine kinase antibody|MERK antibody|MERPEN antibody|Mertk antibody|MERTK c-mer proto-oncogene tyrosine kinase antibody|MERTK_HUMAN antibody|MGC133349 antibody|nmf12 antibody|Nyk antibody|Proto oncogene tyrosine protein kinase MER antibody|Proto oncogene tyrosine protein kinase MER precursor antibody|Proto-oncogene c-Mer antibody|Receptor tyrosine kinase MerTK antibody|RP38 antibody|STK kinase antibody|Tyrosine-protein kinase Mer antibody|Anti-MERTK antibody [Y323] (ab52968)
SCBT cat No: sc-53984|sc-53985|sc-365499|sc-515338|sc-66395|sc-66397|sc-66398|
MerTK Monoclonal Antibody
|Catalogue No.|| |
MerTK Monoclonal Antibody detects endogenous levels of MerTK protein.
Purified recombinant fragment of MerTK expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
MerTK Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MerTK Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase Mer antibody, Proto-oncogene c-Mer antibody, Receptor tyrosine kinase MerTK antibody
|Protein names|| |
Tyrosine-protein kinase Mer , Proto-oncogene c-Mer , Receptor tyrosine kinase MerTK
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
|Involvement in disease|| |
Retinitis pigmentosa 38 (RP38) [MIM:613862]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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