Mouse Monoclonal MMP-1 antibody [6A5] (STJ98247)

$379.00

Reactivity: Human
Applications: WB, IHC, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal MMP-1 antibody [6A5] (STJ98247)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for MMP-1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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MMP1 antibody, CLG antibody,|27 kDa interstitial collagenase antibody|CLG antibody|CLGN antibody|collagenase, fibroblast antibody|collagenase, interstitial antibody|Fibroblast collagenase antibody|Interstitial collagenase antibody|Matrix metallopeptidase 1 (interstitial collagenase) antibody|Matrix metalloprotease 1 antibody|Matrix Metalloproteinase 1 antibody|Matrix metalloproteinase-1 antibody|MMP 1 antibody|MMP-1 antibody|MMP1 antibody|MMP1_HUMAN antibody|OTTHUMP00000045866 antibody|Anti-MMP1 antibody [EP1247Y] (ab52631)
SCBT cat No: sc-21731|sc-6837|sc-12348|sc-8834|sc-58377|sc-137044|sc-30069|

 

Name

MMP-1 Monoclonal Antibody

Catalogue No.

STJ98247

Reactivity

Human

Specificity

MMP-1 Monoclonal Antibody detects endogenous levels of MMP-1 protein.

Immunogen

Purified recombinant fragment of human MMP-1 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

MMP-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

MMP-1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Interstitial collagenase antibody, Fibroblast collagenase antibody, Matrix metalloproteinase-1 antibody, MMP-1 antibody

Database links

Human UniProt/Swiss-Prot:P03956;Mouse UniPort/Swiss-Prot: Q9EPL5;Rat UniProt/Swiss-Port: B5DFD5;Human Entrez Gene: 4312;Mouse Entrez Gene: 83995;Rat Entrez Gene: Rn.79007

Protein names

Interstitial collagenase , Fibroblast collagenase , Matrix metalloproteinase-1 , MMP-1

Protein function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity. / Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-, -Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1′ is a hydrophobic residue. / Ca2+ / Zn2+ / Can be activated without removal of the activation peptide.

Protein sequence and domain

There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases). / The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.

Protein post-translational modifications

Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. / Tyrosine phosphorylated in platelets by PKDCC/VLK.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Synthesis and Degradation>MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize MMP-1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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