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Mouse Monoclonal MMP-9 antibody [5G3] (STJ98248)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MMP9 antibody, CLG4B antibody,|82 kDa matrix metalloproteinase-9 antibody|92 kDa gelatinase antibody|92 kDa type IV collagenase antibody|CLG 4B antibody|CLG4B antibody|Collagenase Type 4 beta antibody|Collagenase type IV 92 KD antibody|EC 126.96.36.199 antibody|Gelatinase 92 KD antibody|Gelatinase B antibody|Gelatinase beta antibody|GelatinaseB antibody|GELB antibody|Macrophage gelatinase antibody|MANDP2 antibody|Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody|Matrix Metalloproteinase 9 antibody|MMP 9 antibody|MMP-9 antibody|MMP9 antibody|MMP9_HUMAN antibody|Type V collagenase antibody|Anti-MMP9 antibody (ab38898)
SCBT cat No: sc-21736|sc-107373|sc-163626|sc-130677|sc-373919|sc-373917|sc-398505|sc-398738|
MMP-9 Monoclonal Antibody
|Catalogue No.|| |
MMP-9 Monoclonal Antibody detects endogenous levels of MMP-9 protein.
Purified recombinant fragment of human MMP-9 expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
MMP-9 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MMP-9 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Matrix metalloproteinase-9 antibody, MMP-9 antibody, 92 kDa gelatinase antibody, 92 kDa type IV collagenase antibody, Gelatinase B antibody, GELB antibody
|Protein names|| |
Matrix metalloproteinase-9 , MMP-9 , 92 kDa gelatinase , 92 kDa type IV collagenase , Gelatinase B , GELB
|Protein function|| |
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-, -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. / Cleavage of gelatin types I and V and collagen types IV and V. / Zn2+ / Ca2+ / Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
|Protein tissue specificity|| |
Produced by normal alveolar macrophages and granulocytes.
|Involvement in disease|| |
Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 3 fibronectin type-II domains. / Contains 4 hemopexin repeats.
|Protein post-translational modifications|| |
Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. / N- and O-glycosylated.
|Protein cellular localization|| |
Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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