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Mouse Monoclonal MYL2 antibody [7C9] (STJ98260)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MYL2 antibody, MLC2 antibody,|Cardiac myosin light chain-2 antibody|Cardiac ventricular myosin light chain 2 antibody|CMH10 antibody|MLC 2v antibody|MLC-2 antibody|MLC-2v antibody|MLC2 antibody|MLRV_HUMAN antibody|MYL 2 antibody|MYL2 antibody|Myosin light chain 2 regulatory cardiac slow antibody|Myosin light polypeptide 2 regulatory cardiac slow antibody|Myosin regulatory light chain 2 antibody|Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody|Regulatory light chain of myosin antibody|RLC of myosin antibody|Slow cardiac myosin regulatory light chain 2 antibody|ventricular/cardiac muscle isoform antibody|Anti-Myosin Light Chain 2 antibody [EPR3741] (ab92721)
SCBT cat No: sc-517205|sc-34490|
MYL2 Monoclonal Antibody
|Catalogue No.|| |
MYL2 Monoclonal Antibody detects endogenous levels of MYL2 protein.
Purified recombinant fragment of MYL2 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
MYL2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
MYL2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform antibody, MLC-2 antibody, MLC-2v antibody, Cardiac myosin light chain 2 antibody, Myosin light chain 2, slow skeletal/ventricular muscle isoform antibody, MLC-2s/v antibody, Ventricular myosin light chain 2 antibody
|Protein names|| |
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform , MLC-2 , MLC-2v , Cardiac myosin light chain 2 , Myosin light chain 2, slow skeletal/ventricular muscle isoform , MLC-2s/v , Ventricular myosin light chain 2
|Protein function|| |
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
|Involvement in disease|| |
Cardiomyopathy, familial hypertrophic 10 (CMH10) [MIM:608758]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 3 EF-hand domains.
|Protein post-translational modifications|| |
N-terminus is methylated by METTL11A/NTM1. / Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).
|Protein cellular localization|| |
Cytoplasm > myofibril > sarcomere > A band
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St John’s Laboratory Ltd.
|Product type|| |
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