Mouse Monoclonal MYL2 antibody [7C9] (STJ98260)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal MYL2 antibody [7C9] (STJ98260)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for MYL2 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

MYL2 antibody, MLC2 antibody,|Cardiac myosin light chain-2 antibody|Cardiac ventricular myosin light chain 2 antibody|CMH10 antibody|MLC 2v antibody|MLC-2 antibody|MLC-2v antibody|MLC2 antibody|MLRV_HUMAN antibody|MYL 2 antibody|MYL2 antibody|Myosin light chain 2 regulatory cardiac slow antibody|Myosin light polypeptide 2 regulatory cardiac slow antibody|Myosin regulatory light chain 2 antibody|Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody|Regulatory light chain of myosin antibody|RLC of myosin antibody|Slow cardiac myosin regulatory light chain 2 antibody|ventricular/cardiac muscle isoform antibody|Anti-Myosin Light Chain 2 antibody [EPR3741] (ab92721)
SCBT cat No: sc-517205|sc-34490|

 

Name

MYL2 Monoclonal Antibody

Catalogue No.

STJ98260

Reactivity

Human

Specificity

MYL2 Monoclonal Antibody detects endogenous levels of MYL2 protein.

Immunogen

Purified recombinant fragment of MYL2 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

MYL2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

MYL2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform antibody, MLC-2 antibody, MLC-2v antibody, Cardiac myosin light chain 2 antibody, Myosin light chain 2, slow skeletal/ventricular muscle isoform antibody, MLC-2s/v antibody, Ventricular myosin light chain 2 antibody

Database links

Human UniProt/Swiss-Prot:P10916;Mouse UniPort/Swiss-Prot: P51667;Rat UniProt/Swiss-Port: P08733;Human Entrez Gene: 4633;Mouse Entrez Gene: 17906;Rat Entrez Gene: Rn.37176

Protein names

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform , MLC-2 , MLC-2v , Cardiac myosin light chain 2 , Myosin light chain 2, slow skeletal/ventricular muscle isoform , MLC-2s/v , Ventricular myosin light chain 2

Protein function

Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).

Involvement in disease

Cardiomyopathy, familial hypertrophic 10 (CMH10) [MIM:608758]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 3 EF-hand domains.

Protein post-translational modifications

N-terminus is methylated by METTL11A/NTM1. / Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).

Protein cellular localization

Cytoplasm > myofibril > sarcomere > A band

Research area

All research areas>Structural Proteins>MYL2
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize MYL2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!