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Mouse Monoclonal N-cadherin antibody [5D5] (STJ98267)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CDH2 antibody, CDHN antibody, NCAD antibody,|CADH2_HUMAN antibody|Cadherin 2 antibody|Cadherin 2 N cadherin neuronal antibody|Cadherin 2 type 1 antibody|Cadherin 2 type 1 N cadherin neuronal antibody|Cadherin 2, type 1, N-cadherin (neuronal) antibody|Cadherin-2 antibody|Cadherin2 antibody|Calcium dependent adhesion protein neuronal antibody|CD325 antibody|CD325 antigen antibody|CDH2 antibody|CDHN antibody|CDw325 antibody|CDw325 antigen antibody|N cadherin 1 antibody|N-cadherin antibody|NCAD antibody|Neural cadherin antibody|OTTHUMP00000066304 antibody|OTTHUMP00000067378 antibody|Anti-N Cadherin antibody (ab18203)
SCBT cat No: sc-31031|sc-271386|sc-1502|sc-135312|sc-390240|sc-31451|sc-16031|sc-28754|sc-31450|sc-161902|
N-cadherin Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein.
Purified recombinant fragment of human N-cadherin expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
N-cadherin Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
N-cadherin Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cadherin-2 antibody, CDw325 antibody, Neural cadherin antibody, N-cadherin antibody, CD antigen CD325 antibody
|Protein names|| |
Cadherin-2 , CDw325 , Neural cadherin , N-cadherin , CD antigen CD325
|Protein function|| |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
|Protein sequence and domain|| |
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity). / Contains 5 cadherin domains.
|Protein post-translational modifications|| |
Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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