Mouse Monoclonal N-cadherin antibody [5D5] (STJ98267)

$379.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal N-cadherin antibody [5D5] (STJ98267)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CDH2 antibody, CDHN antibody, NCAD antibody,|CADH2_HUMAN antibody|Cadherin 2 antibody|Cadherin 2 N cadherin neuronal antibody|Cadherin 2 type 1 antibody|Cadherin 2 type 1 N cadherin neuronal antibody|Cadherin 2, type 1, N-cadherin (neuronal) antibody|Cadherin-2 antibody|Cadherin2 antibody|Calcium dependent adhesion protein neuronal antibody|CD325 antibody|CD325 antigen antibody|CDH2 antibody|CDHN antibody|CDw325 antibody|CDw325 antigen antibody|N cadherin 1 antibody|N-cadherin antibody|NCAD antibody|Neural cadherin antibody|OTTHUMP00000066304 antibody|OTTHUMP00000067378 antibody|Anti-N Cadherin antibody (ab18203)
SCBT cat No: sc-31031|sc-271386|sc-1502|sc-135312|sc-390240|sc-31451|sc-16031|sc-28754|sc-31450|sc-161902|

 

Name

N-cadherin Monoclonal Antibody

Catalogue No.

STJ98267

Reactivity

Human, Mouse, Rat

Specificity

N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein.

Immunogen

Purified recombinant fragment of human N-cadherin expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

N-cadherin Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

N-cadherin Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cadherin-2 antibody, CDw325 antibody, Neural cadherin antibody, N-cadherin antibody, CD antigen CD325 antibody

Database links

Human UniProt/Swiss-Prot:P19022;Mouse UniPort/Swiss-Prot: P15116;Rat UniProt/Swiss-Port: Q9Z1Y3;Human Entrez Gene: 1000;Mouse Entrez Gene: 12558;Rat Entrez Gene: Rn.23200

Protein names

Cadherin-2 , CDw325 , Neural cadherin , N-cadherin , CD antigen CD325

Protein function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Protein sequence and domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity). / Contains 5 cadherin domains.

Protein post-translational modifications

Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Cell Adhesion Proteins>Cadherin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize N-cadherin Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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