Mouse Monoclonal NCoA-3 antibody [2C11B12] (STJ98268)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal NCoA-3 antibody [2C11B12] (STJ98268)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

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NCOA3 antibody, AIB1 antibody, BHLHE42 antibody, RAC3 antibody, TRAM1 antibody,|ACTR antibody|AIB 1 antibody|AIB-1 antibody|AIB1 antibody|Amplified in breast cancer 1 antibody|Amplified in breast cancer 1 protein antibody|bHLHe42 antibody|CAGH 16 antibody|CAGH16 antibody|CBP interacting protein antibody|CBP-interacting protein antibody|Class E basic helix-loop-helix protein 42 antibody|CTG 26 antibody|CTG26 antibody|KAT13B / AIB1 antibody|MGC141848 antibody|NCOA 3 antibody|NCoA-3 antibody|Ncoa3 antibody|NCOA3_HUMAN antibody|Nuclear receptor coactivator 3 antibody|pCIP antibody|RAC 3 antibody|RAC-3 antibody|RAC3 antibody|Receptor associated coactivator 3 antibody|Receptor-associated coactivator 3 antibody|SRC 3 antibody|SRC-3 antibody|SRC3 antibody|Steroid receptor coactivator protein 3 antibody|Thyroid hormone receptor activator molecule 1 antibody|TNRC14 antibody|TNRC16 antibody|TRAM 1 antibody|TRAM-1 antibody|TRAM1 antibody|Anti-SRC3 antibody – ChIP Grade (ab2831)
SCBT cat No: sc-56854|sc-80992|sc-71654|sc-71657|sc-56855|sc-56856|sc-33671|sc-515530|sc-7216|sc-166751|sc-5305|sc-13066|sc-25742|sc-14607|sc-9119|

 

Name

NCoA-3 Monoclonal Antibody

Catalogue No.

STJ98268

Reactivity

Human

Specificity

NCoA-3 Monoclonal Antibody detects endogenous levels of NCoA-3 protein.

Immunogen

Purified recombinant fragment of NCoA-3 (aa1-200) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

NCoA-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

NCoA-3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Nuclear receptor coactivator 3 antibody, NCoA-3 antibody, ACTR antibody, Amplified in breast cancer 1 protein antibody, AIB-1 antibody, CBP-interacting protein antibody, pCIP antibody, Class E basic helix-loop-helix protein 42 antibody, bHLHe42 antibody, Receptor-associated coactivator 3 antibody, RAC-3 antibody, Steroid receptor coactivator protein 3 antibody, SRC-3 antibody, Thyroid hormone receptor activator molecule 1 antibody, TRAM-1 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y6Q9;Human Entrez Gene: 8202;Mouse Entrez Gene: 17979;Rat Entrez Gene: Rn.20691

Protein names

Nuclear receptor coactivator 3 , NCoA-3 , ACTR , Amplified in breast cancer 1 protein , AIB-1 , CBP-interacting protein , pCIP , Class E basic helix-loop-helix protein 42 , bHLHe42 , Receptor-associated coactivator 3 , RAC-3 , Steroid receptor coactivator protein 3 , SRC-3 , Thyroid hormone receptor activator molecule 1 , TRAM-1

Protein function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. / Acetyl-CoA + [histone] = CoA + acetyl-[histone]. / Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.

Protein tissue specificity

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Protein sequence and domain

Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain). / Belongs to the SRC/p160 nuclear receptor coactivator family. / Contains 1 bHLH (basic helix-loop-helix) domain. / Contains 1 PAS (PER-ARNT-SIM) domain.

Protein post-translational modifications

Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. / Methylated by CARM1. / Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Steroid Receptors>NCoA
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize NCoA-3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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