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Mouse Monoclonal NCoA-3 antibody [2C11B12] (STJ98268)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
NCOA3 antibody, AIB1 antibody, BHLHE42 antibody, RAC3 antibody, TRAM1 antibody,|ACTR antibody|AIB 1 antibody|AIB-1 antibody|AIB1 antibody|Amplified in breast cancer 1 antibody|Amplified in breast cancer 1 protein antibody|bHLHe42 antibody|CAGH 16 antibody|CAGH16 antibody|CBP interacting protein antibody|CBP-interacting protein antibody|Class E basic helix-loop-helix protein 42 antibody|CTG 26 antibody|CTG26 antibody|KAT13B / AIB1 antibody|MGC141848 antibody|NCOA 3 antibody|NCoA-3 antibody|Ncoa3 antibody|NCOA3_HUMAN antibody|Nuclear receptor coactivator 3 antibody|pCIP antibody|RAC 3 antibody|RAC-3 antibody|RAC3 antibody|Receptor associated coactivator 3 antibody|Receptor-associated coactivator 3 antibody|SRC 3 antibody|SRC-3 antibody|SRC3 antibody|Steroid receptor coactivator protein 3 antibody|Thyroid hormone receptor activator molecule 1 antibody|TNRC14 antibody|TNRC16 antibody|TRAM 1 antibody|TRAM-1 antibody|TRAM1 antibody|Anti-SRC3 antibody – ChIP Grade (ab2831)
SCBT cat No: sc-56854|sc-80992|sc-71654|sc-71657|sc-56855|sc-56856|sc-33671|sc-515530|sc-7216|sc-166751|sc-5305|sc-13066|sc-25742|sc-14607|sc-9119|
NCoA-3 Monoclonal Antibody
|Catalogue No.|| |
NCoA-3 Monoclonal Antibody detects endogenous levels of NCoA-3 protein.
Purified recombinant fragment of NCoA-3 (aa1-200) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
NCoA-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
NCoA-3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nuclear receptor coactivator 3 antibody, NCoA-3 antibody, ACTR antibody, Amplified in breast cancer 1 protein antibody, AIB-1 antibody, CBP-interacting protein antibody, pCIP antibody, Class E basic helix-loop-helix protein 42 antibody, bHLHe42 antibody, Receptor-associated coactivator 3 antibody, RAC-3 antibody, Steroid receptor coactivator protein 3 antibody, SRC-3 antibody, Thyroid hormone receptor activator molecule 1 antibody, TRAM-1 antibody
|Protein names|| |
Nuclear receptor coactivator 3 , NCoA-3 , ACTR , Amplified in breast cancer 1 protein , AIB-1 , CBP-interacting protein , pCIP , Class E basic helix-loop-helix protein 42 , bHLHe42 , Receptor-associated coactivator 3 , RAC-3 , Steroid receptor coactivator protein 3 , SRC-3 , Thyroid hormone receptor activator molecule 1 , TRAM-1
|Protein function|| |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. / Acetyl-CoA + [histone] = CoA + acetyl-[histone]. / Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.
|Protein tissue specificity|| |
Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
|Protein sequence and domain|| |
Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain). / Belongs to the SRC/p160 nuclear receptor coactivator family. / Contains 1 bHLH (basic helix-loop-helix) domain. / Contains 1 PAS (PER-ARNT-SIM) domain.
|Protein post-translational modifications|| |
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. / Methylated by CARM1. / Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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