Mouse Monoclonal Nkx-2.5 antibody [2E1] (STJ98278)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Nkx-2.5 antibody [2E1] (STJ98278)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Nkx-2.5 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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NKX2-5 antibody, CSX antibody, NKX2.5 antibody, NKX2E antibody,|NKX2.5, mouse, homolog of antibody|NK2, Drosophila, homolog of, E antibody|NKX2-5 antibody|NKX2.5 antibody|NKX25_HUMAN antibody|Nkx2E antibody|NKX4-1 antibody|Tinman paralog antibody|VSD3 antibody|Anti-Nkx2.5 antibody [2E1] (ab91196)
SCBT cat No: sc-12514|sc-376565|sc-365207|sc-14033|sc-8697|

 

Name

Nkx-2.5 Monoclonal Antibody

Catalogue No.

STJ98278

Reactivity

Human

Specificity

Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.

Immunogen

Purified recombinant fragment of human Nkx-25 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Nkx-2.5 Antibody was tube-contained. Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Nkx-2.5 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Homeobox protein Nkx-2.5 antibody, Cardiac-specific homeobox antibody, Homeobox protein CSX antibody, Homeobox protein NK-2 homolog E antibody

Database links

Human UniProt/Swiss-Prot:P52952;Mouse UniPort/Swiss-Prot: P42582;Rat UniProt/Swiss-Port: O35767;Human Entrez Gene: 1482;Mouse Entrez Gene: 18091;Rat Entrez Gene: Rn.6179

Protein names

Homeobox protein Nkx-2.5 , Cardiac-specific homeobox , Homeobox protein CSX , Homeobox protein NK-2 homolog E

Protein function

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.

Protein tissue specificity

Expressed only in the heart.

Involvement in disease

Atrial septal defect 7, with or without atrioventricular conduction defects (ASD7) [MIM:108900]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria, and atrioventricular conduction defects in some cases. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hypothyroidism, congenital, non-goitrous, 5 (CHNG5) [MIM:225250]: A non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG5 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ventricular septal defect 3 (VSD3) [MIM:614432]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger’s syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hypoplastic left heart syndrome 2 (HLHS2) [MIM:614435]: A syndrome due to defective development of the aorta proximal to the entrance of the ductus arteriosus, and hypoplasia of the left ventricle and mitral valve. As a result of the abnormal circulation, the ductus arteriosus and foramen ovale are patent and the right atrium, right ventricle, and pulmonary artery are enlarged. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the NK-2 homeobox family. / Contains 1 homeobox DNA-binding domain.

Protein cellular localization

Nucleus

Research area

All research areas>Homeodomain Proteins>Nkx
(View all antibody categories related to Homeodomain Proteins)

Note

AntibodyPlus can customize Nkx-2.5 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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