Mouse Monoclonal NOS3 antibody [6H2] (STJ98282)

$379.00

Reactivity: Human
Applications: IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal NOS3 antibody [6H2] (STJ98282)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC, ELISA

Recommended dilution: IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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NOS3 antibody,|cNOS antibody|Constitutive NOS antibody|EC NOS antibody|EC-NOS antibody|ecNOS antibody|Endothelial nitric oxidase synthase antibody|Endothelial nitric oxide synthase antibody|Endothelial nitric oxide synthase 3 antibody|Endothelial NOS antibody|eNOS antibody|Nitric oxide synthase 3 (endothelial cell) antibody|Nitric oxide synthase 3 antibody|Nitric oxide synthase 3 endothelial cell antibody|Nitric oxide synthase endothelial antibody|Nitric oxide synthase, endothelial antibody|NOS 3 antibody|NOS III antibody|NOS type III antibody|NOS3 antibody|NOS3_HUMAN antibody|NOSIII antibody|Anti-eNOS antibody [M221] (ab76198)
SCBT cat No: sc-376751|sc-136977|sc-654|sc-376542|sc-8311|sc-653|sc-137118|sc-46423|sc-365363|sc-137111|sc-67003|sc-137117|sc-373954|

 

Name

NOS3 Monoclonal Antibody

Catalogue No.

STJ98282

Reactivity

Human

Specificity

NOS3 Monoclonal Antibody detects endogenous levels of NOS3 protein.

Immunogen

Purified recombinant fragment of human NOS3 expressed in E Coli

Host

Mouse

Applications

IHC, ELISA

Recommended dilution

IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

NOS3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

NOS3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Nitric oxide synthase, endothelial antibody, Constitutive NOS antibody, cNOS antibody, EC-NOS antibody, Endothelial NOS antibody, eNOS antibody, NOS type III antibody, NOSIII antibody

Database links

Human UniProt/Swiss-Prot:P29474;Mouse UniPort/Swiss-Prot: P70313;Rat UniProt/Swiss-Port: Q62600;Human Entrez Gene: 4846;Mouse Entrez Gene: 18127;Rat Entrez Gene: Rn.44265

Protein names

Nitric oxide synthase, endothelial , Constitutive NOS , cNOS , EC-NOS , Endothelial NOS , eNOS , NOS type III , NOSIII

Protein function

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. / Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. / 2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O. / heme / FAD / FMN / 5,6,7,8-tetrahydrobiopterin / Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Protein tissue specificity

Platelets, placenta, liver and kidney.

Involvement in disease

Note: Variation in NOS3 seem to be associated with susceptibility to coronary spasm. .

Protein sequence and domain

Belongs to the NOS family. / Contains 1 FAD-binding FR-type domain. / Contains 1 flavodoxin-like domain.

Protein post-translational modifications

Phosphorylation by AMPK at Ser-1177 in the presence of Ca2+-calmodulin (CaM) activates activity. In absence of Ca2+-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.

Protein cellular localization

Cell membrane / Membrane > caveola / Cytoplasm > cytoskeleton / Golgi apparatus

Research area

All research areas>Synthesis and Degradation>NOS3
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize NOS3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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