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Mouse Monoclonal NOS3 antibody [6H2] (STJ98282)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, ELISA
Recommended dilution: IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
NOS3 antibody,|cNOS antibody|Constitutive NOS antibody|EC NOS antibody|EC-NOS antibody|ecNOS antibody|Endothelial nitric oxidase synthase antibody|Endothelial nitric oxide synthase antibody|Endothelial nitric oxide synthase 3 antibody|Endothelial NOS antibody|eNOS antibody|Nitric oxide synthase 3 (endothelial cell) antibody|Nitric oxide synthase 3 antibody|Nitric oxide synthase 3 endothelial cell antibody|Nitric oxide synthase endothelial antibody|Nitric oxide synthase, endothelial antibody|NOS 3 antibody|NOS III antibody|NOS type III antibody|NOS3 antibody|NOS3_HUMAN antibody|NOSIII antibody|Anti-eNOS antibody [M221] (ab76198)
SCBT cat No: sc-376751|sc-136977|sc-654|sc-376542|sc-8311|sc-653|sc-137118|sc-46423|sc-365363|sc-137111|sc-67003|sc-137117|sc-373954|
NOS3 Monoclonal Antibody
|Catalogue No.|| |
NOS3 Monoclonal Antibody detects endogenous levels of NOS3 protein.
Purified recombinant fragment of human NOS3 expressed in E Coli
|Recommended dilution|| |
IHC 1:200-1:1000; ELISA 1:10000
NOS3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
NOS3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nitric oxide synthase, endothelial antibody, Constitutive NOS antibody, cNOS antibody, EC-NOS antibody, Endothelial NOS antibody, eNOS antibody, NOS type III antibody, NOSIII antibody
|Protein names|| |
Nitric oxide synthase, endothelial , Constitutive NOS , cNOS , EC-NOS , Endothelial NOS , eNOS , NOS type III , NOSIII
|Protein function|| |
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. / Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. / 2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O. / heme / FAD / FMN / 5,6,7,8-tetrahydrobiopterin / Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.
|Protein tissue specificity|| |
Platelets, placenta, liver and kidney.
|Involvement in disease|| |
Note: Variation in NOS3 seem to be associated with susceptibility to coronary spasm. .
|Protein sequence and domain|| |
Belongs to the NOS family. / Contains 1 FAD-binding FR-type domain. / Contains 1 flavodoxin-like domain.
|Protein post-translational modifications|| |
Phosphorylation by AMPK at Ser-1177 in the presence of Ca2+-calmodulin (CaM) activates activity. In absence of Ca2+-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.
|Protein cellular localization|| |
Cell membrane / Membrane > caveola / Cytoplasm > cytoskeleton / Golgi apparatus
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St John’s Laboratory Ltd.
|Product type|| |
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