Mouse Monoclonal NSD1 antibody (STJ98521)

$379.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal NSD1 antibody (STJ98521)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

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NSD1 antibody, ARA267 antibody, KMT3B antibody,|Androgen receptor coactivator 267 kDa protein antibody|Androgen receptor-associated protein of 267 kDa antibody|ARA267 antibody|H3 K36 HMTase antibody|H3-K36-HMTase antibody|H4 K20 HMTase antibody|H4-K20-HMTase antibody|Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody|KMT3B antibody|Lysine N-methyltransferase 3B antibody|NR binding SET domain containing protein antibody|NR-binding SET domain-containing protein antibody|Nsd1 antibody|NSD1_HUMAN antibody|Nuclear receptor binding SET domain containing protein 1 antibody|Nuclear receptor-binding SET domain-containing protein 1 antibody|Anti-KMT3B / NSD1 antibody (ab89432)
SCBT cat No: sc-46016|sc-32479|sc-130470|

 

Name

NSD1 Monoclonal Antibody

Catalogue No.

STJ98521

Reactivity

Human

Specificity

NSD1 Monoclonal Antibody detects endogenous levels of NSD1 protein.

Immunogen

Purified recombinant human NSD1 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

NSD1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

NSD1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody, Androgen receptor coactivator 267 kDa protein antibody, Androgen receptor-associated protein of 267 kDa antibody, H3-K36-HMTase antibody, H4-K20-HMTase antibody, Lysine N-methyltransferase 3B antibody, Nuclear receptor-binding SET domain-containing protein 1 antibody, NR-binding SET domain-containing protein antibody

Database links

Human UniProt/Swiss-Prot:Q96L73;Rat UniProt/Swiss-Port: D4AA06;Human Entrez Gene: 64324;Mouse Entrez Gene: 18193;Rat Entrez Gene: Rn.19435

Protein names

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific , Androgen receptor coactivator 267 kDa protein , Androgen receptor-associated protein of 267 kDa , H3-K36-HMTase , H4-K20-HMTase , Lysine N-methyltransferase 3B , Nuclear receptor-binding SET domain-containing protein 1 , NR-binding SET domain-containing protein

Protein function

Histone methyltransferase. Preferentially methylates ‘Lys-36’ of histone H3 and ‘Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. / S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Protein tissue specificity

Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.

Involvement in disease

Sotos syndrome 1 (SOTOS1) [MIM:117550]: A childhood overgrowth syndrome characterized by pre- and postnatal overgrowth, developmental delay, mental retardation, advanced bone age, and abnormal craniofacial morphology including macrodolichocephaly with frontal bossing, frontoparietal sparseness of hair, apparent hypertelorism, downslanting palpebral fissures, and facial flushing. Common oral findings include: premature eruption of teeth; high, arched palate; pointed chin and, more rarely, prognathism. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Beckwith-Wiedemann syndrome (BWS) [MIM:130650]: A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.; Note: A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product. .

Protein sequence and domain

Belongs to the class V-like SAM-binding methyltransferase superfamily. / Contains 1 AWS domain. / Contains 4 PHD-type zinc fingers. / Contains 1 post-SET domain. / Contains 2 PWWP domains. / Contains 1 SET domain.

Protein cellular localization

Nucleus / Chromosome

Research area

All research areas>Tumor Suppressor/Apoptosis>NSD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize NSD1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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