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Mouse Monoclonal Nup98 antibody (STJ98522)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
NUP98 antibody, ADAR2 antibody,|96 kDa nucleoporin antibody|98 kDa nucleoporin antibody|ADAR2 antibody|ADIR2 antibody|GLFG-repeat containing nucleoporin antibody|Nuclear pore complex protein Nup96 antibody|Nuclear pore complex protein Nup98 Nup96 antibody|Nucleoporin 98kD antibody|nucleoporin 98kDa antibody|Nucleoporin Nup96 antibody|Nucleoporin Nup98 antibody|NUP196 antibody|NUP96 antibody|Nup98 antibody|Nup98-Nup96 antibody|NUP98_HUMAN antibody|Anti-NUP98 antibody [2H10] (ab50610)
SCBT cat No: sc-101546|sc-14155|sc-27400|sc-74578|sc-74553|sc-30112|
Nup98 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Dog
Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein.
Purified recombinant human Nup98 protein fragments expressed in Ecoli
|Recommended dilution|| |
Nup98 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Nup98 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nuclear pore complex protein Nup98-Nup96 antibody
|Protein names|| |
Nuclear pore complex protein Nup98-Nup96
|Protein function|| |
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.
|Involvement in disease|| |
Note: A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. .; Note: A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. .; Note: A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. .; Note: A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. .; Note: A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. .; Note: A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. .
|Protein sequence and domain|| |
Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport. / Belongs to the nucleoporin GLFG family. / Contains 1 peptidase S59 domain.
|Protein post-translational modifications|| |
Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. / Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
|Protein cellular localization|| |
Nucleus membrane / Peripheral membrane protein; Nucleoplasmic side / Nucleus > nuclear pore complex
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St John’s Laboratory Ltd.
|Product type|| |
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