Mouse Monoclonal Oct-3/4 antibody [1D10H6] (STJ98285)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Oct-3/4 antibody [1D10H6] (STJ98285)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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POU5F1 antibody, OCT3 antibody, OCT4 antibody, OTF3 antibody,|Octamer binding transcription factor 4 antibody|MGC22487 antibody|Oct 3 antibody|Oct 4 antibody|Oct-3 antibody|Oct-4 antibody|OCT3 antibody|Oct4 antibody|Octamer binding protein 3 antibody|Octamer binding protein 4 antibody|Octamer binding transcription factor 3 antibody|Octamer-binding protein 3 antibody|Octamer-binding protein 4 antibody|Octamer-binding transcription factor 3 antibody|OTF 3 antibody|OTF 4 antibody|OTF-3 antibody|OTF3 antibody|OTF4 antibody|PO5F1_HUMAN antibody|POU class 5 homeobox 1 antibody|POU domain class 5 transcription factor 1 antibody|POU domain transcription factor OCT4 antibody|POU domain, class 5, transcription factor 1 antibody|POU-type homeodomain-containing DNA-binding protein antibody|POU5F1 antibody|Anti-Oct4 antibody – ChIP Grade (ab19857)
SCBT cat No: sc-101534|sc-365509|sc-5279|sc-8629|sc-514295|sc-9081|sc-25401|sc-8628|sc-8630|

 

Name

Oct-3/4 Monoclonal Antibody

Catalogue No.

STJ98285

Reactivity

Human

Specificity

Oct-3/4 Monoclonal Antibody detects endogenous levels of Oct-3/4 protein.

Immunogen

Purified recombinant fragment of Oct-3/4 (aa193-360) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Oct-3/4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Oct-3/4 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

POU domain, class 5, transcription factor 1 antibody, Octamer-binding protein 3 antibody, Oct-3 antibody, Octamer-binding protein 4 antibody, Oct-4 antibody, Octamer-binding transcription factor 3 antibody, OTF-3 antibody

Database links

Human UniProt/Swiss-Prot:Q01860;Mouse UniPort/Swiss-Prot: P20263;Rat UniProt/Swiss-Port: Q6MG27;Human Entrez Gene: 5460;Mouse Entrez Gene: 18999;Rat Entrez Gene: Rn.161748

Protein names

POU domain, class 5, transcription factor 1 , Octamer-binding protein 3 , Oct-3 , Octamer-binding protein 4 , Oct-4 , Octamer-binding transcription factor 3 , OTF-3

Protein function

Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Protein tissue specificity

Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

Protein sequence and domain

The POU-specific domain mediates interaction with PKM. / Belongs to the POU transcription factor family. Class-5 subfamily. / Contains 1 homeobox DNA-binding domain. / Contains 1 POU-specific domain.

Protein post-translational modifications

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity). / Ubiquitinated; undergoes ‘Lys-63’-linked polyubiquitination by WWP2 leading to proteasomal degradation. / ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Homeodomain Proteins>Oct
(View all antibody categories related to Homeodomain Proteins)

Note

AntibodyPlus can customize Oct-3/4 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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