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Mouse Monoclonal Oct-3/4 antibody [7E7] (STJ98287)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
POU5F1 antibody, OCT3 antibody, OCT4 antibody, OTF3 antibody,|Octamer binding transcription factor 4 antibody|MGC22487 antibody|Oct 3 antibody|Oct 4 antibody|Oct-3 antibody|Oct-4 antibody|OCT3 antibody|Oct4 antibody|Octamer binding protein 3 antibody|Octamer binding protein 4 antibody|Octamer binding transcription factor 3 antibody|Octamer-binding protein 3 antibody|Octamer-binding protein 4 antibody|Octamer-binding transcription factor 3 antibody|OTF 3 antibody|OTF 4 antibody|OTF-3 antibody|OTF3 antibody|OTF4 antibody|PO5F1_HUMAN antibody|POU class 5 homeobox 1 antibody|POU domain class 5 transcription factor 1 antibody|POU domain transcription factor OCT4 antibody|POU domain, class 5, transcription factor 1 antibody|POU-type homeodomain-containing DNA-binding protein antibody|POU5F1 antibody|Anti-Oct4 antibody – ChIP Grade (ab19857)
SCBT cat No: sc-101534|sc-365509|sc-5279|sc-8629|sc-514295|sc-9081|sc-25401|sc-8628|sc-8630|
Oct-3/4 Monoclonal Antibody
|Catalogue No.|| |
Oct-3/4 Monoclonal Antibody detects endogenous levels of Oct-3/4 protein.
Synthesized peptide derived from internal of human Oct-3/4
WB, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Oct-3/4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Oct-3/4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
POU domain, class 5, transcription factor 1 antibody, Octamer-binding protein 3 antibody, Oct-3 antibody, Octamer-binding protein 4 antibody, Oct-4 antibody, Octamer-binding transcription factor 3 antibody, OTF-3 antibody
|Protein names|| |
POU domain, class 5, transcription factor 1 , Octamer-binding protein 3 , Oct-3 , Octamer-binding protein 4 , Oct-4 , Octamer-binding transcription factor 3 , OTF-3
|Protein function|| |
Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
|Protein tissue specificity|| |
Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
|Protein sequence and domain|| |
The POU-specific domain mediates interaction with PKM. / Belongs to the POU transcription factor family. Class-5 subfamily. / Contains 1 homeobox DNA-binding domain. / Contains 1 POU-specific domain.
|Protein post-translational modifications|| |
Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity). / Ubiquitinated; undergoes ‘Lys-63’-linked polyubiquitination by WWP2 leading to proteasomal degradation. / ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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