Mouse Monoclonal OCT1 antibody [2C5] (STJ98284)

$379.00

Reactivity: Human
Applications: WB, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal OCT1 antibody [2C5] (STJ98284)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, FC, ELISA

Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for OCT1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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SLC22A1 antibody, OCT1 antibody,|hOCT1 antibody|OCT1 antibody|oct1_cds antibody|Organic cation transporter 1 antibody|S22A1_HUMAN antibody|Slc22a1 antibody|solute carrier family 22 (organic cation transporter), member 1 antibody|Solute carrier family 22 member 1 antibody|Anti-SLC22A1 antibody (ab55916)
SCBT cat No: sc-293181|sc-232|sc-28334|

 

Name

OCT1 Monoclonal Antibody

Catalogue No.

STJ98284

Reactivity

Human

Specificity

OCT1 Monoclonal Antibody detects endogenous levels of 41183 protein.

Immunogen

Purified recombinant fragment of human OCT1 expressed in E Coli

Host

Mouse

Applications

WB, FC, ELISA

Recommended dilution

WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

OCT1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

OCT1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Solute carrier family 22 member 1 antibody, Organic cation transporter 1 antibody, hOCT1 antibody

Database links

Human UniProt/Swiss-Prot:O15245;Mouse UniPort/Swiss-Prot: O08966;Rat UniProt/Swiss-Port: Q63089;Human Entrez Gene: 6580;Mouse Entrez Gene: 20517;Rat Entrez Gene: Rn.11186

Protein names

Solute carrier family 22 member 1 , Organic cation transporter 1 , hOCT1

Protein function

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase. / 1.47 mM for metformin / 229 µM for TEA / 14.6 µM for MPP / 396 pmol/min/mg enzyme for metformin uptake / 2.89 nmol/min/mg enzyme for TEA uptake

Protein tissue specificity

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.

Protein sequence and domain

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Protein post-translational modifications

Phosphorylated.

Protein cellular localization

Basolateral cell membrane / Multi-pass membrane protein

Note

AntibodyPlus can customize OCT1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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