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Mouse Monoclonal OCT1 antibody [2C5] (STJ98284)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, FC, ELISA
Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for OCT1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
SLC22A1 antibody, OCT1 antibody,|hOCT1 antibody|OCT1 antibody|oct1_cds antibody|Organic cation transporter 1 antibody|S22A1_HUMAN antibody|Slc22a1 antibody|solute carrier family 22 (organic cation transporter), member 1 antibody|Solute carrier family 22 member 1 antibody|Anti-SLC22A1 antibody (ab55916)
SCBT cat No: sc-293181|sc-232|sc-28334|
OCT1 Monoclonal Antibody
|Catalogue No.|| |
OCT1 Monoclonal Antibody detects endogenous levels of 41183 protein.
Purified recombinant fragment of human OCT1 expressed in E Coli
WB, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
OCT1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
OCT1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Solute carrier family 22 member 1 antibody, Organic cation transporter 1 antibody, hOCT1 antibody
|Protein names|| |
Solute carrier family 22 member 1 , Organic cation transporter 1 , hOCT1
|Protein function|| |
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase. / 1.47 mM for metformin / 229 µM for TEA / 14.6 µM for MPP / 396 pmol/min/mg enzyme for metformin uptake / 2.89 nmol/min/mg enzyme for TEA uptake
|Protein tissue specificity|| |
Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
|Protein sequence and domain|| |
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Basolateral cell membrane / Multi-pass membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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