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Mouse Monoclonal OPG antibody [5A11] (STJ98291)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for OPG Monoclonal Antibody.
Check alternative names for the antibodyExpand
TNFRSF11B antibody, OCIF antibody, OPG antibody,|MGC29565 antibody|OCIF antibody|OPG antibody|Osteoclastogenesis inhibitory factor antibody|Osteoprotegerin antibody|PDB5 antibody|TNF receptor superfamily member 11b antibody|TNFRSF 11B antibody|TNFRSF11B antibody|TR 1 antibody|TR1 antibody|TR11B_HUMAN antibody|Tumor necrosis factor receptor superfamily member 11B antibody|Anti-Osteoprotegerin antibody (ab73400)
SCBT cat No: sc-71747|sc-390518|sc-11383|sc-8468|sc-21038|sc-53976|
OPG Monoclonal Antibody
|Catalogue No.|| |
OPG Monoclonal Antibody detects endogenous levels of OPG protein.
Purified recombinant fragment of human OPG expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
OPG Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
OPG Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tumor necrosis factor receptor superfamily member 11B antibody, Osteoclastogenesis inhibitory factor antibody, Osteoprotegerin antibody
|Protein names|| |
Tumor necrosis factor receptor superfamily member 11B , Osteoclastogenesis inhibitory factor , Osteoprotegerin
|Protein function|| |
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
|Protein tissue specificity|| |
Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
|Involvement in disease|| |
Paget disease of bone 5, juvenile-onset (PDB5) [MIM:239000]: An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 2 death domains. / Contains 4 TNFR-Cys repeats.
|Protein post-translational modifications|| |
N-glycosylated. Contains sialic acid residues. / The N-terminus is blocked.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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