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Mouse Monoclonal p16 antibody [1E12E10] (STJ98296)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for p16 Monoclonal Antibody.
Check alternative names for the antibodyExpand
CDKN2A antibody, CDKN2 antibody, MLM antibody,||
SCBT cat No: To be updated
p16 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
p16 Monoclonal Antibody detects endogenous levels of p16 protein.
Purified recombinant fragment of p16 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
p16 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
p16 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tumor suppressor ARF antibody, Alternative reading frame antibody, ARF antibody, Cyclin-dependent kinase inhibitor 2A antibody, p14ARF antibody
|Protein names|| |
Tumor suppressor ARF , Alternative reading frame , ARF , Cyclin-dependent kinase inhibitor 2A , p14ARF
|Protein function|| |
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its ‘Lys63’-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.
|Protein post-translational modifications|| |
Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardeless of the absence of lysine residues. Ubiquitination leads to its degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.
|Protein cellular localization|| |
Nucleus > nucleolus / Nucleus > nucleoplasm / Mitochondrion
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St John’s Laboratory Ltd.
|Product type|| |
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