Mouse Monoclonal p16 antibody [2D9A12] (STJ98295)


Reactivity: Human, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal p16 antibody [2D9A12] (STJ98295)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for p16 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody


CDKN2A antibody, CDKN2 antibody, MLM antibody,||
SCBT cat No: To be updated



p16 Monoclonal Antibody

Catalogue No.



Human, Rat


p16 Monoclonal Antibody detects endogenous levels of p16 protein.


Purified recombinant fragment of p16 expressed in E Coli





Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000








p16 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


p16 Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tumor suppressor ARF antibody, Alternative reading frame antibody, ARF antibody, Cyclin-dependent kinase inhibitor 2A antibody, p14ARF antibody

Database links

Human UniProt/Swiss-Prot:Q8N726;Mouse UniPort/Swiss-Prot: P51480;Rat UniProt/Swiss-Port: Q9R0Z3;Human Entrez Gene: 1029;Mouse Entrez Gene: 12578;Rat Entrez Gene: Rn.48717

Protein names

Tumor suppressor ARF , Alternative reading frame , ARF , Cyclin-dependent kinase inhibitor 2A , p14ARF

Protein function

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its ‘Lys63’-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.

Protein post-translational modifications

Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardeless of the absence of lysine residues. Ubiquitination leads to its degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.

Protein cellular localization

Nucleus > nucleolus / Nucleus > nucleoplasm / Mitochondrion

Research area

All research areas>Cell Cycle Proteins>p15
(View all antibody categories related to Cell Cycle Proteins)


AntibodyPlus can customize p16 Antibody according to your requirement, including bulk product size,etc. Please contact AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.


St John’s Laboratory Ltd.

Product type

Primary antibody


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