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Mouse Monoclonal p57 antibody [3E3] (STJ98302)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for p57 Monoclonal Antibody.
Check alternative names for the antibodyExpand
CDKN1C antibody, KIP2 antibody,|Beckwith Wiedemann syndrome antibody|BWCR antibody|BWS antibody|CDKI antibody|CDKN 1C antibody|CDKN1C antibody|CDN1C_HUMAN antibody|Cyclin dependent kinase inhibitor 1C antibody|Cyclin dependent kinase inhibitor p57 antibody|Cyclin-dependent kinase inhibitor 1C antibody|Cyclin-dependent kinase inhibitor p57 antibody|KIP 2 antibody|KIP2 antibody|p57 antibody|p57 Kip 2 antibody|p57KIP2 antibody|WBS antibody|Anti-p57 Kip2 antibody [EP2515Y] (ab75974)
SCBT cat No: sc-1037|
p57 Monoclonal Antibody
|Catalogue No.|| |
p57 Monoclonal Antibody detects endogenous levels of p57 protein.
Purified recombinant fragment of human p57 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
p57 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
p57 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cyclin-dependent kinase inhibitor 1C antibody, Cyclin-dependent kinase inhibitor p57 antibody, p57Kip2 antibody
|Protein names|| |
Cyclin-dependent kinase inhibitor 1C , Cyclin-dependent kinase inhibitor p57 , p57Kip2
|Protein function|| |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
|Protein tissue specificity|| |
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
|Involvement in disease|| |
Beckwith-Wiedemann syndrome (BWS) [MIM:130650]: A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]: A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the CDI family.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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