Mouse Monoclonal p57 antibody [3E3] (STJ98302)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal p57 antibody [3E3] (STJ98302)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for p57 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CDKN1C antibody, KIP2 antibody,|Beckwith Wiedemann syndrome antibody|BWCR antibody|BWS antibody|CDKI antibody|CDKN 1C antibody|CDKN1C antibody|CDN1C_HUMAN antibody|Cyclin dependent kinase inhibitor 1C antibody|Cyclin dependent kinase inhibitor p57 antibody|Cyclin-dependent kinase inhibitor 1C antibody|Cyclin-dependent kinase inhibitor p57 antibody|KIP 2 antibody|KIP2 antibody|p57 antibody|p57 Kip 2 antibody|p57KIP2 antibody|WBS antibody|Anti-p57 Kip2 antibody [EP2515Y] (ab75974)
SCBT cat No: sc-1037|

 

Name

p57 Monoclonal Antibody

Catalogue No.

STJ98302

Reactivity

Human

Specificity

p57 Monoclonal Antibody detects endogenous levels of p57 protein.

Immunogen

Purified recombinant fragment of human p57 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

p57 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

p57 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cyclin-dependent kinase inhibitor 1C antibody, Cyclin-dependent kinase inhibitor p57 antibody, p57Kip2 antibody

Database links

Human UniProt/Swiss-Prot:P49918;Mouse UniPort/Swiss-Prot: P49919;Rat UniProt/Swiss-Port: Q69DC0;Human Entrez Gene: 1028;Mouse Entrez Gene: 12577;Rat Entrez Gene: Rn.162507

Protein names

Cyclin-dependent kinase inhibitor 1C , Cyclin-dependent kinase inhibitor p57 , p57Kip2

Protein function

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Protein tissue specificity

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Involvement in disease

Beckwith-Wiedemann syndrome (BWS) [MIM:130650]: A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]: A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the CDI family.

Protein cellular localization

Nucleus

Research area

All research areas>Cell Cycle Proteins>p57
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize p57 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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