Mouse Monoclonal PA28gamma antibody (STJ98526)

$379.00

Reactivity: Human, Mouse, Dog, Pig
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PA28gamma antibody (STJ98526)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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PSME3 antibody,|11S regulator complex gamma subunit antibody|11S regulator complex subunit gamma antibody|Activator of multicatalytic protease subunit 3 antibody|Ki antibody|Ki antigen antibody|Ki nuclear autoantigen antibody|Ki, PA28 gamma antibody|PA28 gamma antibody|PA28g antibody|PA28gamma antibody|Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody|Proteasome (prosome, macropain) activator subunit 3 antibody|Proteasome activator 28 gamma antibody|Proteasome activator 28 subunit gamma antibody|Proteasome activator complex subunit 3 antibody|Proteasome activator subunit 3 antibody|PSME3 antibody|PSME3_HUMAN antibody|REG GAMMA antibody|REG-gamma antibody|Anti-PSME3 antibody (ab157157)
SCBT cat No: sc-136025|sc-367087|sc-21273|

 

Name

PA28gamma Monoclonal Antibody

Catalogue No.

STJ98526

Reactivity

Human, Mouse, Dog, Pig

Specificity

PA28gamma Monoclonal Antibody detects endogenous levels of PA28gamma protein.

Immunogen

Purified recombinant human PA28gamma protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PA28gamma Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PA28gamma Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Proteasome activator complex subunit 3 antibody, 11S regulator complex subunit gamma antibody, REG-gamma antibody, Activator of multicatalytic protease subunit 3 antibody, Ki nuclear autoantigen antibody, Proteasome activator 28 subunit gamma antibody, PA28g antibody, PA28gamma antibody

Database links

Human UniProt/Swiss-Prot:P61289;Mouse UniPort/Swiss-Prot: P61290;Rat UniProt/Swiss-Port: Q5FVM2;Human Entrez Gene: 10197;Mouse Entrez Gene: 19192;Rat Entrez Gene: Rn.198325

Protein names

Proteasome activator complex subunit 3 , 11S regulator complex subunit gamma , REG-gamma , Activator of multicatalytic protease subunit 3 , Ki nuclear autoantigen , Proteasome activator 28 subunit gamma , PA28g , PA28gamma

Protein function

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition .

Protein tissue specificity

Up-regulated in thyroid carcinoma cells.

Protein sequence and domain

The C-terminal sequences affect heptamer stability and proteasome affinity. / Belongs to the PA28 family.

Protein post-translational modifications

Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2. / Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Signaling Intermediates>PA28
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PA28gamma Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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