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Mouse Monoclonal PA28gamma antibody (STJ98526)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PSME3 antibody,|11S regulator complex gamma subunit antibody|11S regulator complex subunit gamma antibody|Activator of multicatalytic protease subunit 3 antibody|Ki antibody|Ki antigen antibody|Ki nuclear autoantigen antibody|Ki, PA28 gamma antibody|PA28 gamma antibody|PA28g antibody|PA28gamma antibody|Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) antibody|Proteasome (prosome, macropain) activator subunit 3 antibody|Proteasome activator 28 gamma antibody|Proteasome activator 28 subunit gamma antibody|Proteasome activator complex subunit 3 antibody|Proteasome activator subunit 3 antibody|PSME3 antibody|PSME3_HUMAN antibody|REG GAMMA antibody|REG-gamma antibody|Anti-PSME3 antibody (ab157157)
SCBT cat No: sc-136025|sc-367087|sc-21273|
PA28gamma Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Dog, Pig
PA28gamma Monoclonal Antibody detects endogenous levels of PA28gamma protein.
Purified recombinant human PA28gamma protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500
PA28gamma Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PA28gamma Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Proteasome activator complex subunit 3 antibody, 11S regulator complex subunit gamma antibody, REG-gamma antibody, Activator of multicatalytic protease subunit 3 antibody, Ki nuclear autoantigen antibody, Proteasome activator 28 subunit gamma antibody, PA28g antibody, PA28gamma antibody
|Protein names|| |
Proteasome activator complex subunit 3 , 11S regulator complex subunit gamma , REG-gamma , Activator of multicatalytic protease subunit 3 , Ki nuclear autoantigen , Proteasome activator 28 subunit gamma , PA28g , PA28gamma
|Protein function|| |
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition .
|Protein tissue specificity|| |
Up-regulated in thyroid carcinoma cells.
|Protein sequence and domain|| |
The C-terminal sequences affect heptamer stability and proteasome affinity. / Belongs to the PA28 family.
|Protein post-translational modifications|| |
Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2. / Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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