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Mouse Monoclonal PARP-1 antibody (KLH) [7A10] (STJ98308)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, FC, ELISA
Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PARP1 antibody, ADPRT antibody, PPOL antibody,|ADP-ribosyltransferase diphtheria toxin-like 1 antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|APOPAIN antibody|ARTD1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly [ADP-ribose] polymerase 1 antibody|Poly ADP ribose polymerase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody|SCA1 antibody|Anti-Cleaved PARP antibody [E51] (ab32064)
SCBT cat No: sc-23461|sc-56196|sc-56217|sc-52953|sc-71965|sc-23465|sc-23464|sc-23335|sc-73850|sc-49413|sc-49414|sc-393134|sc-390005|
PARP-1 Monoclonal Antibody
|Catalogue No.|| |
PARP-1 Monoclonal Antibody detects endogenous levels of PARP-1 protein.
Synthetic peptide of human PARP-1, conjugated to KLH
WB, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
PARP-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
PARP-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Poly polymerase 1 antibody, PARP-1 antibody, ADP-ribosyltransferase diphtheria toxin-like 1 antibody, ARTD1 antibody, NADantibody, + antibody, ADP-ribosyltransferase 1 antibody, ADPRT 1 antibody, Poly synthase 1 antibody
|Protein names|| |
Poly polymerase 1 , PARP-1 , ADP-ribosyltransferase diphtheria toxin-like 1 , ARTD1 , NAD, + , ADP-ribosyltransferase 1 , ADPRT 1 , Poly synthase 1
|Protein function|| |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. / NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|Protein sequence and domain|| |
Contains 1 BRCT domain. / Contains 1 PARP alpha-helical domain. / Contains 1 PARP catalytic domain. / Contains 2 PARP-type zinc fingers.
|Protein post-translational modifications|| |
Phosphorylated by PRKDC and TXK. / Poly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites. / S-nitrosylated, leading to inhibit transcription regulation activity.
|Protein cellular localization|| |
Nucleus / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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