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Mouse Monoclonal Pax-4 antibody [3C12] (STJ98309)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Pax-4 Monoclonal Antibody.
Check alternative names for the antibodyExpand
PAX4 antibody,|KPD antibody|MGC129960 antibody|MODY9 antibody|Paired box 4 antibody|Paired box gene 4 antibody|paired box homeotic gene 4 antibody|Paired box protein Pax-4 antibody|Paired domain gene 4 antibody|Pax4 antibody|PAX4_HUMAN antibody|Anti-PAX4 antibody (ab42450)
SCBT cat No: sc-27832|
Pax-4 Monoclonal Antibody
|Catalogue No.|| |
Pax-4 Monoclonal Antibody detects endogenous levels of Pax-4 protein.
Purified recombinant fragment of human Pax-4 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Pax-4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Pax-4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Paired box protein Pax-4 antibody
|Protein names|| |
Paired box protein Pax-4
|Protein function|| |
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
|Involvement in disease|| |
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Diabetes mellitus, ketosis-prone (KPD) [MIM:612227]: An atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Maturity-onset diabetes of the young 9 (MODY9) [MIM:612225]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the paired homeobox family. / Contains 1 homeobox DNA-binding domain. / Contains 1 paired domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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