Mouse Monoclonal Pax-6 antibody [1C8] (STJ98310)

$379.00

Reactivity: Human
Applications: WB, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Pax-6 antibody [1C8] (STJ98310)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, FC, ELISA

Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PAX6 antibody, AN2 antibody,|AN 2 antibody|AN antibody|AN2 antibody|Aniridia type II protein antibody|D11S812E antibody|FVH1 antibody|MGC17209 antibody|MGDA antibody|Oculorhombin antibody|Paired box 6 antibody|Paired box gene 6 (aniridia keratitis) antibody|Paired Box Gene 6 antibody|Paired box homeotic gene 6 antibody|Paired box protein Pax-6 antibody|Paired box protein Pax6 antibody|PAX 6 antibody|PAX6 antibody|PAX6_HUMAN antibody|Sey antibody|WAGR antibody|Anti-PAX6 antibody (ab5790)
SCBT cat No: sc-81649|

 

Name

Pax-6 Monoclonal Antibody

Catalogue No.

STJ98310

Reactivity

Human

Specificity

Pax-6 Monoclonal Antibody detects endogenous levels of Pax-6 protein.

Immunogen

Purified recombinant fragment of human Pax-6 expressed in E Coli

Host

Mouse

Applications

WB, FC, ELISA

Recommended dilution

WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Pax-6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Pax-6 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Paired box protein Pax-6 antibody, Aniridia type II protein antibody, Oculorhombin antibody

Database links

Human UniProt/Swiss-Prot:P26367;Mouse UniPort/Swiss-Prot: P63015;Rat UniProt/Swiss-Port: P63016;Human Entrez Gene: 5080;Mouse Entrez Gene: 18508;Rat Entrez Gene: Rn.89724

Protein names

Paired box protein Pax-6 , Aniridia type II protein , Oculorhombin

Protein function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Protein tissue specificity

Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.

Involvement in disease

Aniridia (AN) [MIM:106210]: A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Peters anomaly (PETAN) [MIM:604229]: Consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Foveal hypoplasia 1 (FVH1) [MIM:136520]: An isolated form of foveal hypoplasia, a developmental defect of the eye defined as the lack of foveal depression with continuity of all neurosensory retinal layers in the presumed foveal area. Clinical features include absence of foveal pit on optical coherence tomography, absence of foveal hyperpigmentation, absence of foveal avascularity, absence of foveal and macular reflexes, decreased visual acuity, and nystagmus. Anterior segment anomalies and cataract are observed in some FVH1 patients. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Keratitis hereditary (KERH) [MIM:148190]: An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Coloboma, ocular, autosomal dominant (COAD) [MIM:120200]: A set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). The clinical presentation is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Coloboma of optic nerve (COLON) [MIM:120430]: An ocular defect that is due to malclosure of the fetal intraocular fissure affecting the optic nerve head. In some affected individuals, it appears as enlargement of the physiologic cup with severely affected eyes showing huge cavities at the site of the disk. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Bilateral optic nerve hypoplasia (BONH) [MIM:165550]: A congenital anomaly in which the optic disk appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the paired homeobox family. / Contains 1 homeobox DNA-binding domain. / Contains 1 paired domain.

Protein post-translational modifications

Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.

Protein cellular localization

Nucleus

Research area

All research areas>Homeodomain Proteins>Pax
(View all antibody categories related to Homeodomain Proteins)

Note

AntibodyPlus can customize Pax-6 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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