Mouse Monoclonal PDC-E2 antibody (STJ98527)

$379.00

Reactivity: Human, Rabbit
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PDC-E2 antibody (STJ98527)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DLAT antibody, DLTA antibody,||
SCBT cat No: To be updated

 

Name

PDC-E2 Monoclonal Antibody

Catalogue No.

STJ98527

Reactivity

Human, Rabbit

Specificity

PDC-E2 Monoclonal Antibody detects endogenous levels of PDC-E2 protein.

Immunogen

Purified recombinant human PDC-E2 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PDC-E2 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PDC-E2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial antibody, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody, PBC antibody, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody, M2 antigen complex 70 kDa subunit antibody, Pyruvate dehydrogenase complex component E2 antibody, PDC-E2 antibody, PDCE2 antibody

Database links

Human UniProt/Swiss-Prot:P10515;Mouse UniPort/Swiss-Prot: Q8BMF4;Rat UniProt/Swiss-Port: P08461;Human Entrez Gene: 1737;Mouse Entrez Gene: 235339;Rat Entrez Gene: Rn.15413

Protein names

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , PBC , Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , Pyruvate dehydrogenase complex component E2 , PDC-E2 , PDCE2

Protein function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle. / Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. / (R)-lipoate

Involvement in disease

Note: Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients’ serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantibodies against the E2 component of pyruvate dehydrogenase complex.; Pyruvate dehydrogenase E2 deficiency (PDHE2 deficiency) [MIM:245348]: Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. In this form of PDH deficiency episodic dystonia is the major neurological manifestation, with other more common features of pyruvate dehydrogenase deficiency, such as hypotonia and ataxia, being less prominent. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the 2-oxoacid dehydrogenase family. / Contains 2 lipoyl-binding domains.

Protein post-translational modifications

Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity.

Protein cellular localization

Mitochondrion matrix

Research area

All research areas>Signaling Intermediates>PDC-E2
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PDC-E2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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