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Mouse Monoclonal PDH-E1alpha antibody (STJ98528)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PDHA1 antibody, PHE1A antibody,|ODPA_HUMAN antibody|PDH antibody|PDHA antibody|PDHA1 antibody|PDHCE1A antibody|PDHE1 A type I antibody|PDHE1-A type I antibody|PHE1A antibody|Pyruvate Dehydrogenase (lipoamide) alpha 1 antibody|Pyruvate dehydrogenase complex, E1 alpha polypeptide 1 antibody|Pyruvate Dehydrogenase E1 alpha antibody|Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody|Phospho anti-Pyruvate Dehydrogenase E1-alpha subunit (S293) antibody (ab92696)
SCBT cat No: sc-377092|sc-133898|sc-292543|
PDH-E1alpha Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Dog, Pig
PDH-E1alpha Monoclonal Antibody detects endogenous levels of PDH-E1alpha protein.
Purified recombinant human PDH-E1alpha (C-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500
PDH-E1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
PDH-E1alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody, PDHE1-A type I antibody
|Protein names|| |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I
|Protein function|| |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle. / Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. / thiamine diphosphate / Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.
|Protein tissue specificity|| |
|Involvement in disease|| |
Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]: An enzymatic defect causing primary lactic acidosis in children. It is associated with a broad clinical spectrum ranging from fatal lactic acidosis in the newborn to chronic neurologic dysfunction with structural abnormalities in the central nervous system without systemic acidosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein post-translational modifications|| |
Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Dephosphorylation at all three sites, i.e. at Ser-232, Ser-293 and Ser-300, is required for reactivation. / Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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