Mouse Monoclonal PDH-E1alpha antibody (STJ98528)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PDH-E1alpha antibody (STJ98528)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PDH-E1alpha Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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PDHA1 antibody, PHE1A antibody,|ODPA_HUMAN antibody|PDH antibody|PDHA antibody|PDHA1 antibody|PDHCE1A antibody|PDHE1 A type I antibody|PDHE1-A type I antibody|PHE1A antibody|Pyruvate Dehydrogenase (lipoamide) alpha 1 antibody|Pyruvate dehydrogenase complex, E1 alpha polypeptide 1 antibody|Pyruvate Dehydrogenase E1 alpha antibody|Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody|Phospho anti-Pyruvate Dehydrogenase E1-alpha subunit (S293) antibody (ab92696)
SCBT cat No: sc-377092|sc-133898|sc-292543|

 

Name

PDH-E1alpha Monoclonal Antibody

Catalogue No.

STJ98528

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig

Specificity

PDH-E1alpha Monoclonal Antibody detects endogenous levels of PDH-E1alpha protein.

Immunogen

Purified recombinant human PDH-E1alpha (C-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

PDH-E1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

PDH-E1alpha Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody, PDHE1-A type I antibody

Database links

Human UniProt/Swiss-Prot:P08559;Mouse UniPort/Swiss-Prot: P35486;Rat UniProt/Swiss-Port: Q4FZZ4;Human Entrez Gene: 5160;Mouse Entrez Gene: 18597;Rat Entrez Gene: Rn.3655

Protein names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I

Protein function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle. / Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. / thiamine diphosphate / Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.

Protein tissue specificity

Ubiquitous.

Involvement in disease

Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]: An enzymatic defect causing primary lactic acidosis in children. It is associated with a broad clinical spectrum ranging from fatal lactic acidosis in the newborn to chronic neurologic dysfunction with structural abnormalities in the central nervous system without systemic acidosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Dephosphorylation at all three sites, i.e. at Ser-232, Ser-293 and Ser-300, is required for reactivation. / Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).

Protein cellular localization

Mitochondrion matrix

Research area

All research areas>Signaling Intermediates>PDH-E1 alpha
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PDH-E1alpha Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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