Mouse Monoclonal PDH-E1alpha antibody (STJ98528)


Reactivity: Human, Mouse, Rat, Cow, Dog, Pig
Applications: WB, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal PDH-E1alpha antibody (STJ98528)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


PDHA1 antibody, PHE1A antibody,|ODPA_HUMAN antibody|PDH antibody|PDHA antibody|PDHA1 antibody|PDHCE1A antibody|PDHE1 A type I antibody|PDHE1-A type I antibody|PHE1A antibody|Pyruvate Dehydrogenase (lipoamide) alpha 1 antibody|Pyruvate dehydrogenase complex, E1 alpha polypeptide 1 antibody|Pyruvate Dehydrogenase E1 alpha antibody|Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody|Phospho anti-Pyruvate Dehydrogenase E1-alpha subunit (S293) antibody (ab92696)
SCBT cat No: sc-377092|sc-133898|sc-292543|



PDH-E1alpha Monoclonal Antibody

Catalogue No.



Human, Mouse, Rat, Cow, Dog, Pig


PDH-E1alpha Monoclonal Antibody detects endogenous levels of PDH-E1alpha protein.


Purified recombinant human PDH-E1alpha (C-terminus) protein fragments expressed in Ecoli





Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500






PDH-E1alpha Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.


1 mg/ml


PDH-E1alpha Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody, PDHE1-A type I antibody

Database links

Human UniProt/Swiss-Prot:P08559;Mouse UniPort/Swiss-Prot: P35486;Rat UniProt/Swiss-Port: Q4FZZ4;Human Entrez Gene: 5160;Mouse Entrez Gene: 18597;Rat Entrez Gene: Rn.3655

Protein names

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I

Protein function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle. / Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. / thiamine diphosphate / Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.

Protein tissue specificity


Involvement in disease

Pyruvate dehydrogenase E1-alpha deficiency (PDHAD) [MIM:312170]: An enzymatic defect causing primary lactic acidosis in children. It is associated with a broad clinical spectrum ranging from fatal lactic acidosis in the newborn to chronic neurologic dysfunction with structural abnormalities in the central nervous system without systemic acidosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Dephosphorylation at all three sites, i.e. at Ser-232, Ser-293 and Ser-300, is required for reactivation. / Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).

Protein cellular localization

Mitochondrion matrix

Research area

All research areas>Signaling Intermediates>PDH-E1 alpha
(View all antibody categories related to Signaling Intermediates)


AntibodyPlus can customize PDH-E1alpha Antibody according to your requirement, including bulk product size,etc. Please contact AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.


St John’s Laboratory Ltd.

Product type

Primary antibody


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